280 results
The objective of this study is to evaluate the efficacy of oral cabozantinib at adaily dose of 60 mg compared with 140 mg in subjects with progressive,metastatic MTC.
The primary objective of the trial is to evaluate a preliminary signal of potential anti-tumor activity of MK-3475 in subjects with PD-L1 positive advanced solid tumors. Secondary objectives include safety and tolerability, progression-free survival…
Primary Objective: to determine the maximum tolerated dose (MTD) and the associated dose-limiting toxicities (DLTs) of S 81694.Secondary Objectives:- To define the safety and tolerability profile of S 81694;- To define the recommended phase II dose…
To collect a platform of 2D/3D cell cultures (organoids) of Soft Tissue Sarcomas.To collect a platform of Patient Derived Xenografts (PDX) of Soft Tissue Sarcomas of patients with (non-) metastatic sarcomas.To study the take rate of fresh PDX tumour…
The purpose of this study is to investigate how quickly and to what extent rogaratinib is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Rogaratinib will be labelled with 14 Carbon (…
To determine the absolute bioavailability of imatinib (Glivec®) at steady state after concomitant administration of a single 100 µg microdose of imatinib-d8
To investigate the effect of food on the PK of a single dose of AZD1775 printed capsules following oral dosing in patients with advanced solid tumours
Primary Objectives:Part 1- Estimate the relative bioavailability of the tablet formulation of TAK-931 in reference to the PIC formulation.Part 2- Assess the effect of a high-fat meal on the single dose PK of TAK-931 administered as the tablet…
To ascertain whether the pharmacokinetics of gemcitabine in a therapeutic dose can be predicted from the pharmacokinetics of a microdose.
The main objective is to establish the feasibility of 166Ho-microspheres for intra-tumoural injections in OSCC by defining the total amount of leakage. The secondary objectives are to assess the safety profile by recording the adverse events, and…
- evaluation of the safety of extended use of ModraDoc006/r - provide longterm access to ModraDoc006/r treatment for patients who have completed a phase I trial with ModraDoc006/r and who might have benefit from longterm treatment with weekly…
The objective of this study is to investigate the feasibility of treating breast and lung cancerpatients in mDIBH using nasal a high-flow therapy (NHFT) device.
The aim of this randomised controlled trial is to evaluate the safety, feasibility and effect on quality of life of an exercise training program for 12 weeks in palliative care for patients with advanced cancer. This will be achieved by measuring…
To determine the effect of a high-fat meal on the exposure to docetaxel given as ModraDoc006 tablets in combination with ritonavir in patients with cancer.
Primary objective: Estimate the MTD and/or RDE of LDK378 as a single agent when administered orally to pediatric patients with ALK-activated tumors in the fasted and in fed stateSecondary objectives: Objective 1: Characterize the safety and…
Primary objective· • To investigate the safety and tolerability and establish either the dose of KU-0059436 which causes inhibition of PARP in combination with an active dose of carboplatin or the maximum tolerated dose (MTD) of KU-0059436 in…
Primary: To optimize MR-sequence protocols for MR-guided adaptive radiotherapy, using the integrated Phillips MRI scanner of the MR-Linac (MRL) system. Secondary: To develop an optimal MRL workflow for online MRI-guided adaptive radiotherapy
Primary objective To determine the MTD and/or to identify the RDE of HDM201 in one or more of the pre-defined regimensSecondary objectives * To characterize the safety and tolerability of HDM201* To characterize the pharmacokinetic (PK) properties…
Primary Objective: • To explore the effectiveness of EMDR therapy treatment in reducing symptoms of chemotherapy-induced conditioned nausea and vomiting in (former) patients with cancer.Secondary Objective:• To explore impact on QoL of chemotherapy-…
Primary Objective: To determine the recommended phase II dose (RP2D) of thermoradiotherapy in LA-HNSCC patients. Secondary Objective(s): • Evaluate the Local control, Disease Free Survival and Overall Survival of thermoradiotherapy. • Objective…