99 results
To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…
2 Objectives2.1 Primary objective •To evaluate FAZA-PET/CT as a prognostic factor of the loco-regional control rate at 2 years in HNSCC patients receiving chemo-radiotherapy ± nimorazole.•Time to locoregional recurrence is counted from the day of…
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
Demonstrate an increase of 2-year overall survival (OS) of 15 % (from 50% to 65 %) vs historical controls of the addition of nitroglycerin to radiotherapy (±chemotherapy) of stage I-IV NSCLC.
Primary Objective:To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node…
Primary objective:To assess the safety, tolerability and pharmacokinetics of a single IV dosages of OTL-038. Selected doses of OTL-038 will be studied in the absence and presence of prophylactic treatment with the antihistamine clemastine to be…
The primary objectives are:- to identify predictive factors for fatigue in cancer survivors on long-term sick leave. - to develop a prognostic instrument by which insurance physicians can assess future functional abilities, related to the work…
By means of this study we would like to answer the following questions:- Differs the humoral or cellular immune response after influenza vaccination between fatigued patients (with PCF or CFS) and non-fatigued patients?- Differs the humoral or…
An alternative for guide-wire localisation might be the use of radio-active seed (I-125) implantation. This marker can easily be identified by means of a gamma-probe. This radio-active seeds are cilindric capsules (approximately 4 mm with a diameter…
To study the diagnostic capacity of DW-MRI for detecting recurrence in patients with suspicion of recurrent or persistent HNSCC after initial (chemo)radiation. This study aims to enhance early, low cost detection of recurrence and avoid futile…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
To evaluate if a low-carbohydrate diet leeds to less physiological FDG-uptake in the myocard. Patients on a low-carbohydrate diet will be compared to patients without such a diet.
- To determine the prevalence of (pre)cachexia - To determine whether potential biomarkers of pre-cachexia can be identified
Non invasive imaging of hypoxia with the aid of PET-scans could help to select the patients having a hypoxic tumor who could be treated with specific anti-hypoxic treatments. The added value of additional anti-hypoxic treatments depends on the…
The primary aim of the study is to compare the performance of the standard oblique-viewing US endoscope versus a prototype forward viewing ultrasonic endoscope for EUS-FNA of solid lesions of the GI tract and of adjacent organs.
To detect high-risk pathogenic mutations in germline DNA of children with childhood cancer that are suggestive of genetic predisposition, using NGS-based whole-exome sequencing, resulting in novel targets for future functional and translational…
To study the effect of early tumour development on brown adipose tissue activity
Primary:- Can carboplatin exposure in children be predicted by taking the plasma concentrations of creatinine of cystatine C into account?Secundary:- Which is the effective carboplatin exposure in the current pediatric treatment protocols?- Is there…
To measure structural (volume) and functional (ADC value) changes in the primary tumor on T1- and T2-weighted MRI and diffusion-weighted MRI during and after (chemo)radiotherapy for oropharyngeal squamous cell carcinoma. By using serial imaging…