24 results
To investigate the effect of enzalutamide on the pharmacokinetics (PK) of oxycodone following a single 15 mg oral dose of normal-release oxycodone in men with prostate cancer.
Our main objective is to dissect the genomic determinants of treatment-related adverse events after lymphoma, specifically cardiovascular disease and second malignant neoplasms. As such, we will assess the association of genetic and epigenetic…
Objectives: The primary objectives of this study are: • Part 1 (dose-escalation): To evaluate the safety of SYD985 in combination with niraparib to determine the maximum tolerated dose (MTD) and recommended combination dose regimen for expansion (…
To gain insight into the incidence of retinopathy and optic neuropathy in relation to the radiation dose in order to develop a normal tissue complication probability (NTCP) model for the eye and the optic tract.
This study has been transitioned to CTIS with ID 2024-512824-13-01 check the CTIS register for the current data. The overarching goal of this study is to improve adequate resection of oral cancer. We will perform a clinical trial to determine the…
Primary Objectives:Phase 1/ Dose escalation:• To determine the safety and tolerability of INT-1B3, administered as single agent by 120-min i.v. infusion• To identify the Recommended Phase 2 Dose (RP2D) of INT-1B3 Phase 1b/ Dose expansion:• To…
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…
Primary end point• Progression-free survival (PFS) per ICR central assessmentSecondary end point• Objective response rate (ORR)• Disease control rate (DCR)• Overall survival (OS)• PFS according to Investigator assessment of radiologic images•…
The aim of the study is to investigate the clinical feasibility of irradiation without a mask for head and neck cancer patients. Optical surface scanning will be used and the set-up accuracy, intra-fractional motion, patient friendliness, and…
1. To demonstrate the added value of intraoperative pancreatoscopy in patients undergoing partial pancreatic resection for the treatment of Intraductal Papillary Mucinous Neoplasm (IPMN) as it pertains to detection of discontinuous (skip) lesions in…
The primary objective of this study is to identify biomarkers predictive for response to chemo-immunotherapy in patients with lungcancer with a known driver mutation.Secondary endpoints are overall survival; time to biological progression, defined…
The goal of this pilot study is to 1. Investigate the feasibility of the lymphatic mapping procedure in locally advanced cervical cancer 2. Study the agreement of the lymphatic map with the radiotherapy treatment plan. Are all lymph nodes at risk…
Primary Objective: To assess the sensitivity and specificity of rhPSMA-7.3 (18F) PET in detecting N1 disease on a patient level compared to the histopathology of pelvic lymphatic tissue removed during RP and PLND. At least one positive pelvic LN on…
This study has been transitioned to CTIS with ID 2023-509605-77-00 check the CTIS register for the current data. Primary objectives (Dose-escalation Phase):• To evaluate the safety and tolerability, describe the dose-limiting toxicities (DLTs), to…
To assess immune response and adverse events after administration of one approved vaccine against COVID-19 in patients with cancer treated with immunotherapy and/or chemotherapy
To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.Primary Objective: - To…
Primary objective: To evaluate the effect of navitoclax in combination with ruxolitinib on splenomegaly response when compared to ruxolitinib in subjects with myelofibrosis.Secondary objectives:• To evaluate the effect of navitoclax in combination…
This study has been transitioned to CTIS with ID 2024-514733-38-00 check the CTIS register for the current data. Primary* Compare progression-free survival (PFS) by investigator assessment per Response Evaluation Criteria inSolid Tumors (RECIST) v1.…
The purpose of this study is to investigate how quickly and to what extent HDM201 is absorbed, broken down and eliminated from the body (this is called pharmacokinetics). HDM201 will be labeled with 14-carbon (14C) and is thus radioactive. In this…
This explorative study aims to investigate the added value of a 18F-PSMA PET to mpMRI in the detection of local prostate cancer lesions.