13 results
Primary objectivesTo characterize the bone marrow microenvironment in advanced stage myelofibrosis (MF) before and during treatment with ruxolitinib, regarding osteoblastic activity, marrow fibrosis and - osteosclerosis and perfusion- and diffusion…
We here wish to apply new advancements in multi-color flow cytometry for a detailed and sensitive examination of mast cells in peripheral blood of patients with SM.
The aim of the current study is to improve the diagnosis of iron overload in MDS patients. The primary objectives are to evaluate 1. the relationship between red blood cell transfusions and iron overload in liver and heart as investigated by MRI T2…
The family, described in a publication from 1987, is recently re-identified. It seems to be an asymptomatic condition: there seems to be no anemia or secondary iron overload. Again mapping this family has two purposes:1. Have these patients…
To determine the levels, cellular origin and procoagulant function of microparticles in ET and PV, and to explore the existence of a correlation with jak2V617F mutation, medication and vascular events.
The primary objective is to evaluate the safety and efficacy of anakinra in patients with multiple myeloma receiving high-dose melphalan (HDM) in the preparation for an autologous hematopoietic stem cell transplantation (SCT). Secondary objectives…
Assess the efficacy of PBMT to prevent/ameliorate dysgeusia in patients with multiple myeloma treated in Amsterdam UMC with conditioning chemo(radio)therapy followed by autologous stem-cell-transplantation.
To better treat and understand bleeding and thrombotic complications of these diseases and treatments, more insight is needed into the pathophysiology. WIth the findings of the current study we would like to increase knowledge on how platelets (and…
The primary objective is to evaluate the efficacy of anakinra in patients with multiple myeloma receiving high-dose melphalan (HDM) in the preparation for an autologous hematopoietic stem cell transplantation (SCT). The primary endpoint is the…
The primary objective is to investigate the role of the hematopoeitic niche and mast cells in the bone marrow of MPN, and the effect of pharmacotherapy on these cells.
To investigate which molecular mast cell phenotypes (as defined by the expressed genes and gene-networks) in bone marrow resident mast cells and their progenitors are associated with the presence or absence of ISM.
The primary objective is to assess the adaptive T cell response to VIT in HVA patients with underlying ISM (ISM+) after treatment induction (at thirteen weeks) and upon reaching maintenance dose, after seven months, in comparison to the baseline…
The main objective of our study is to gain more insight into the molecular processes preceding the onset and course of LCH. Moreover, we try to understand the role of the immune system, if any, in the clearance of histiocytes which are typically…