13 results
Primary objectives:1: To determine whether CT- coronary angiography by MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease. 2: To establish the…
The aim of this project is a prospective study of blood samples of HL patients to determine the value sensitivity and specificity of increase TARC an MDC serum levels for the early detection of a relapse.
The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…
The objective of this study is to measure quality of life, health care use and morbidity (like fatigue, anxiety and depression) of patients diagnosed at least 2 years ago. These variables will be compared between the different treatment modalities…
To respectively evaluate the fertility parameters before and after treatment for pediatric HL in the Netherlands according to the COG protocols for low risk, intermediate risk and high risk, to test the hypothesis that these protocols will not harm…
The aims of this study are to compare the diagnostic performance of whole-body MRI (including DWIBS) to FDG-PET/CT and/or CT for the initial staging, early response assessment and restaging after completion of therapy in children with Hodgkin*s…
The aim of this project is to identify biomarkers and novel therapeutic targets for pediatric Hodgkin lymphoma. To achieve this aim we defined three objectives:1.Hodgkin Reed-Sternberg cells: To perform whole exome sequencing and gene expression…
The aim of this study is to reduce the indication for RT without compromising cure rates. To investigate if intensified consolidation therapy (DECOPDAC-21) compared to standard consolidation therapy (COPDAC-28) can compensate for reduction in RT.
This study has been transitioned to CTIS with ID 2024-511151-18-00 check the CTIS register for the current data. • Determine a feasible 89Zr-brentuximab-PET imaging schedule, to allow assessment of the biodistribution of 89Zr-brentuximab in tumor…
To study the interaction between normal T lymphocytes and Hodgkin tumor cells in an in vitro model.
Development of blood-based monitoring techniques for treatment response evaluation and diagnostics in lymphoid neoplasms, including HL and NHL by using extracellular vesicle and cfDNA techniques for biomarker discovery, assay development and…
To evaluate TARC in patients with fever, lymphadenopathy or non-Hodgkin lymphoma
The aim of the trial is to individualize treatment for each patient by adapting it to early response and thus to continue intensive treatment only with those patients wo show an inadequate treatment response.For patients who show a good initial…