238 results
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…
To study the effect of ELC during mechanical ventilation (MV) on fluid balance in severe sepsis or septic shock.
Primary Objectives:1) To determine immunogenicity of NIP vaccines in preterm infants when vaccinated according to the current Dutch NIP schedule and with rotavirus vaccine following the RIVAR study.2) To unravel the mechanism of immature host…
Primary objective:To establish the safety and toxicity profile of 166Ho-RE in patients with hepatocellular carcinoma. Secondary objectives:* To evaluate efficacy of 166Ho-RE in hepatocellular carcinoma without curative treatment options in a non-…
The primary objective of this project is to evaluate the primary and secondary technique effectiveness of IRE for centrally located colorectal liver metastases that are neither amenable for resection nor for other local ablation methods due to the…
Primary objective: To compare the NP microbiome composition and the presence of viruses in children hospitalized for a LRTI to the NP microbiome composition and the presence of viruses in healthy age- and gender-matched controls. Secondary…
The primary study objective is to compare the efficacy, as assessed by overall survival, of surgery and neo-adjuvant chemotherapy to surgery alone in patients with resectable liver metastases of colorectal cancer and a high clinical risk score.…
Primary objective • To determine the overall response rate of two PHP with an at least 6 week interval and 3 mg/kg melphalan in irresectable liver metastases patients. • To determine the percentage of patients qualifying for resection. Secondary…
Primary objectives:* To evaluate efficacy of adjuvant 166Ho-radioembolization (166Ho-RE) after systemic 177Lu-dotatate in a non-comparative phase II study Secondary objectives:* To establish the safety and toxicity profile of adjuvant 166Ho-RE after…
In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…
The objective of the study is to assess the additional value of monitoring segmental liver function with HBS in patients undergoing SIRT.
1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…
The generic objective of the study is to explore associations between exposure to livestock farms and potential health effects. This study will focus on 1) respiratory health effects, 2) Livestock associated infections (zoonoses), 3) Carriage of…
The aim of this study is to get insight into the long-term clinical course of HAML*s in order to develop a treatment algorithm. Primary Objective: The main study parameters are recurrence, growth or development of new HAML tumors.
Determination of the seroprevalence and occupational risk factors for zoonotic transmission of hantavirus (including SEOV) and pathogenic Leptospira in professional groups that have high-risk contact with muskrats and/or coypu and the bycatch of…
To assess the time to progression after TACE-DEB and after SBRT in a comparable population of patients diagnosed with HCC.
To determine safety and technical feasibility of stereotactic radiotherapy for locally advanced and locally recurrent pancreatic carcinoma.
In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…
Objective: To determine which co-stimulatory and -inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with CCA, and to study the effects of targeting these molecules on their function in ex vivo assays.