227 results
To determine which costimulatory and co-inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with HCC or CCA, and to study the effects of targeting these molecules on their function in ex vivo assays.
The aim of this study is to describe the PK/PD characteristics of frequently used beta-lactam antibiotics in PICU patients. The main objective is to identify whether current antibiotic dosing regimens of the selected beta-lactams achieve defined…
Our proposal builds on 12 years of sustained EU funding, a consortium covering 11 European countries and 27partners (with non-EU sites in African and two Asian populations to provide a global perspective) and our cuttingedge new research, which has…
We aim to introduce 166Ho radioembolization combined with systemic chemotherapy and investigate its safety and feasibility.
The primary objective of this study is to determine the accuracy of the delta PCO2 (PaCO2-tcPCO2) and delta PO2 (tcPO2 -cPO2) levels for the detection of sepsis. The secondary aims are to determine the factors that influence delta PCO2 and delta PO2…
This study aims to delineate the alterations in leukocyte function during ex-vivo host-pathogen interactions. These data will be correlated with several factors such as coexisting comorbidities (e.g. diabetes) and functional defects analyzed using…
The objectives of this study are1)To asses the sensitivity, specificity, positive and negative predictive values of HIV, HBV, HCV, syphilis and creatinine screening tests performed on dried blood client-collected samples at home, as compared to…
The main aim of the proposed study is to 1) assess the habitual consumption of raw cow*s milk among a large population of adult dairy farmers; 2) assess the association between raw cow*s milk consumption and inflammation-related, auto-immune and…
The primary objective of this study is to demonstrate the clinical utility of the addition of per oral cholangioscopy (POCS) to standard ERCP with brushing cytology for diagnosis and early detection of cholangiocarcinoma in patients diagnosed with…
This study has been transitioned to CTIS with ID 2024-516110-38-00 check the CTIS register for the current data. Primary Objectives:-To evaluate if the treatment of Low Risk HB can be reduced (Group B1)-To compare different induction treatment…
The primary aim of this study is to identify host and pathogen related determinants of disease severity of ARI. In this study we will include a prospectively defined and sufficiently sized patient cohort that will allow investigations of relative…
Primary Objective: 1) To assess the short- and long-term prevalence of AMR genes in the microbiome of the gut in infants exposed to broad-spectrum antibiotics in the first week of life compared to controls. 2) To investigate the short- and long-term…
The primary objective of this study is to validate the accuracy of FebriDx to discriminate between viral and/or bacterial respiratory infections. Besides this, the predictive value (negative predictive value (NPV) and positive predictive value (PPV…
Primary Objective: The first objective of this study is to evaluate efficacy of adjuvant HAIP chemotherapy after repeat hepatectomy for recurrent CRLM in the Erasmus MC.Secondary Objective(s): The second objective is to determine treatment related…
Multimodality Preoperative Evaluation of lymph nodes of perihilar cholangiocarcinoma - a pilot study
The primairy aim of this pilot study is to evaluate the feasibility of systematic survey by EUS-FNA/FNB.
To isolate and validate TCRs that exclusively recognize liver antigens presented by specific (*recipient*) HLA-molecules (LSARH) on the surface of tumor cells.
This study will assess the benefit of adding SIRT to a standard regimen of cisplatin and gemcitabine (CIS-GEM) systemic chemotherapy in unresectable liver-only or liver predominant intrahepatic cholangiocarcinoma.Patients will be offered the…
The objective of the study is to evaluate TheraSphere in the treatment of patients with unresectablehepatocellular carcinoma in whom treatment with standard-of-care sorafenib therapy is planned.
Identification of host biomarkers, being membrane bound proteins, on both neutrophils and CD64 expressing cells, that have discriminatory difference in concentrations.
The aim of this study is to determine the added value of low-dose CT and PoC-PCR in the diagnostic workup of patients with CAP hospitalised to non-intensive care unit (ICU) wards in minimizing selective antibiotic pressure while maintaining patient…