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Intraprocedural assessment of Ablation Margins using COMPuted tomography co-registration in primary LivEr Tumor treatment with percutanEous ablation: IAMCOMPLETE primary

To investigate the feasibility of co-registration with MIRADA XD of pre- and post-ablation CT using an optimized scanning protocol. Secondary objectives will be to investigate the reproducibility of CT-CT co-registration, to determine the duration…

Navigation for percutaneous liver ablation

The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.

Inter- and intra-fraction fiducial position reproducibility in end-exhalation breath hold for Ethos liver radiotherapy

To determine inter- and intra-fraction fiducial and patient position reproducibility in order to determine appropriate safety margins for liver SBRT treatment on Ethos.

The RALLY study: dose finding study for radiation lobectomy using holmium-166 microspheres to improve resectability in patients with HCC.

Primary Objective:To establish the maximum tolerated healthy liver-absorbed dose of 166Ho-microspheres in patients with HCC who receive RL as a bridge to resection.Secondary Objective(s): 1) To establish dose-response relationships between:a. The…

A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With Intrahepatic Cholangiocarcinoma (ICC) and Other Advanced Solid Tumors

This study has been transitioned to CTIS with ID 2024-512622-29-00 check the CTIS register for the current data. To determine the maximum tolerated dose (MTD) and Recommended Phase 2 Dose (RP2D) of RLY-4008 and to determine RLY-4008's safety…

Real-time MR imaged treatment with holmium microspheres of patients with primary liver cancer; a single center, interventional, non-randomized, feasibility study

To investigate the safety and feasibility of a personalized Ho-166-PLLA-MS TARE approach by using MRI guidance in inoperable patients with HCC.

an open label, randomised, phase 2 study to evaluate the safety and efficacy of mtl-cebpa administered in combination with sorafenib or sorafenib alone, in TKI naïve participants with previously treated advanced hepatocellular carcinoma (HCC) and hepatitis B or hepatitis C virus (outreach2)

We compare the efficacy and safety of the new medication MTL-CEBPA in combination with sorafenib with the efficacy and safety of sorafenib alone. Sorafenib is already being used for the treatment of HCC.

LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection

The aim of the current study is to assess whether MI combined liver and colorectal resection for CRLMs and primary colorectal tumor can result in shorter time to functional recovery and hereby results indirectly in a lower postoperative complication…

A phase I trial evaluating the safety, tolerability and pharmacokinetics of intravenously administered M6229 in critically ill sepsis patients - *HistoSeps*

Primary Objectives:Our primary objectives are:1. To evaluate the safety, tolerability and pharmacokinetics of intravenously (IV) administered M6229 in critically ill patients with sepsis with specific attention to anti-coagulation effects (based on…

EUS-guided choledochoduodenostomy for primary drainage of malignant distal biliary obstruction: a pilot study using FCSEMS through LAMS

To reduce stent dysfunction after EUS-CDS by placing a FCSEMS through the LAMS, while maintaining effectiveness and safety of EUS-CDS as primary drainage strategy in patients with malignant distal biliary obstruction.

PLASOMA Efficacy & Technology Health study.
A post-market randomised controlled efficacy study of PLASOMA on wound healing in chronic venous leg ulcers.

This study is designed to examine beneficial effects of PLASOMA treatment compared to the standard of care on chronic venous leg ulcers (VLU) that match the size of the plasma area of the pad.The intention is that the data obtained with this study…

Right Dose, Right Now: Randomized Controlled Clinical Trial

To assess the influence of dosing guided by AutoK on achieving PK targets and clinical endpoints in intensive care patients with sepsis.

Endoscopic drainage of presumed resectable perihilar cholangiocarcinoma using a intrahepatic plastic stent with retrieval string; a pilot study (CHORDA-II-pilot)

To explore feasibility and efficacy of endoscopic drainage of patients with presumed perihilar cholangiocarcinoma eligible for major liver resection using a plastic stent with a retrieval string.

Adjuvant chemotherapy with gemcitabine and cisplatin compared to
standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)

This study has been transitioned to CTIS with ID 2024-517340-61-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the efficacy of gemcitabine and cisplatin compared with standard of care (adjuvant…

An exploratory pharmacokinetics and pharmacodynamics study of beta-lactam antibiotics in pediatric intensive care patients: is there a need for more precision? (EXPAT-Kids)

The aim of this study is to describe the PK/PD characteristics of frequently used beta-lactam antibiotics in PICU patients. The main objective is to identify whether current antibiotic dosing regimens of the selected beta-lactams achieve defined…

THE ADDED VALUE OF 166HO TRANS-ARTERIAL RADIOEMBOLIZATION TO SYSTEMIC THERAPY IN LIVER METASTATIC BREAST CANCER PATIENTS

We aim to introduce 166Ho radioembolization combined with systemic chemotherapy and investigate its safety and feasibility.

Paediatric Hepatic International Tumour Trial

This study has been transitioned to CTIS with ID 2024-516110-38-00 check the CTIS register for the current data. Primary Objectives:-To evaluate if the treatment of Low Risk HB can be reduced (Group B1)-To compare different induction treatment…

Adjuvant hepatic arterial infusion pump chemotherapy after repeat hepatectomy for patients with recurrent colorectal liver metastases without a history of extrahepatic disease - a phase II study

Primary Objective: The first objective of this study is to evaluate efficacy of adjuvant HAIP chemotherapy after repeat hepatectomy for recurrent CRLM in the Erasmus MC.Secondary Objective(s): The second objective is to determine treatment related…

Adoptive Transfer of T cell Receptor-engineered T cells to treat hepAtocellular Carcinoma recurrence after liver Transplantation: a preclinical feasibility study

To isolate and validate TCRs that exclusively recognize liver antigens presented by specific (*recipient*) HLA-molecules (LSARH) on the surface of tumor cells.

A prospective, multicentre, randomised, controlled study evaluating SIR-Spheres® Y-90 resin microspheres preceding standard cisplatin-gemcitabine (CIS-GEM) chemotherapy versus CIS-GEM chemotherapy alone as first-line treatment of patients with unresectable intrahepatic CholangioCArcinoma.

This study will assess the benefit of adding SIRT to a standard regimen of cisplatin and gemcitabine (CIS-GEM) systemic chemotherapy in unresectable liver-only or liver predominant intrahepatic cholangiocarcinoma.Patients will be offered the…