19 results
The aim of this study is to get insight into the long-term clinical course of HAML*s in order to develop a treatment algorithm. Primary Objective: The main study parameters are recurrence, growth or development of new HAML tumors.
Determination of the seroprevalence and occupational risk factors for zoonotic transmission of hantavirus (including SEOV) and pathogenic Leptospira in professional groups that have high-risk contact with muskrats and/or coypu and the bycatch of…
Objective: To determine which co-stimulatory and -inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with CCA, and to study the effects of targeting these molecules on their function in ex vivo assays.
To investigate whether raw milk, pasteurized milk or ultra-heat treated (UHT) milk is able to enhance the systemic immune response as induced by oral cholera vaccination, in comparison to regular vaccination. Oral vaccination can also induce an…
1) To obtain insight into the age-specific seroprevalence (immunity) for selected vaccine-preventable diseases among adult refugees in order to determine the need for targeted vaccination campaigns among identified risk groups (age, country of…
To objectively investigate retinal function deterioration due to the inflammatory process by ERG. To investigate if risk factors for loss of ERG activity in uveitis herald more aggressive immunomodulation treatment to prevent visual loss.
To diminish the number of asthma exacerbations with the regular use of a bacterial lysate.
Primary Objective:1. To assess the safety and tolerability of single escalating doses of Adrecizumab in healthy male volunteers during experimental endotoxemia.Secondary Objectives:2. To determine the pharmacokinetics of single escalating doses of…
This study aims to improve the diagnosis and management of febrile children across Europe and West Africa through the development of simple diagnostic tests to discriminate febrile illnesses in children, including bacterial and viral infection and…
The objective of this trial is to assess the immunological activity of Vvax001 by monitoring HPV-16 specific immune responses in order to determine the optimal dose inducing the highest immune responses.
In this study we hope to demonstrate the presence ofthat ctDNA can be reliably detected in patients with perihilar cholangiocarcinoma.
The primary aim of this study is to identify host and pathogen related determinants of disease severity of ARI. In this study we will include a prospectively defined and sufficiently sized patient cohort that will allow investigations of relative…
Primary objectives * surrogate endpoint (at interim analysis)To evaluate the efficacy of elafibranor QD for 72 weeks versus placebo on resolution of NASH without worsening of fibrosis.* Resolution of NASH is defined as the disappearance of…
To compare the sensitivity of ERCP brush cytology between standard RX cytology brush and Inifinity brush in patients with pancreatobiliary strictures suspicious for malignancy.
The objective of the study is to evaluate TheraSphere in the treatment of patients with unresectablehepatocellular carcinoma in whom treatment with standard-of-care sorafenib therapy is planned.
To elucidate the host and environmental factors that influence the magnitude of the individual trained immunity responses to BCG vaccination using a systems biology approach.
The aim of this double-blinded pilot randomized controlled trial (RCT) is to compare the effects of a conventional LCVP vs. a GDFT protocol in open liver surgery on surgical and anesthesiological conditions and its relation to outcome. Primary…
The aim of this project is to study the effects of shift work on body weight and infection susceptibility and the mechanisms underlying these health effects. First, we will study the relation between shift work exposure and body weight and between…
Primary Objective:To measure distances between the pointer tip held on surgical clips placed on the liver surface and the closest tumor border using navigation, and compare it to the actual distance measured in intraoperative XperCT. Secondary…