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Preonditioning for patients who will undergo esophaguscardiaresection

The purpose of this research is to investigate the effect and feasability of multimodal preconditioning for patients who will undergo esophaguscardiaresection.

Neoadjuvant chemoradiation for patients with adenocarcinoma of the stomach. A feasibility and efficacy study.

Purpose: To evaluate the feasibility and efficacy of a combination of preoperative chemoradiation of Paclitaxel 50mg/m2 and Carboplatin AUC 2 given intravenously on day 1, 8,15, 22 and 29 in combination with 45 Gy (fractions of 1.8Gy) for locally…

Phase I/II study of oxaliplatin combined with melphalan in isolated hepatic perfusion for the treatment of liver metastases.

Firstly, determination of the maximum tolerated dose (MTD) , dose limiting toxicity (DLT) and farmacokinetics in IHP with sequential administration of oxaliplatin and melphalan.Secondly, evaluation of toxicity, tumor response and survival after IHP…

Phase III multicentre, Randomised, Double Blind, Comparative study to assess the efficacy and safety of lanreotide 30mg versus placebo as a palliative treatment of clinical symptoms associated with intestinal obstruction due to peritoneal carcinomatosis in inoperable patients

Primary objective:The primary objective of this study is to assess the efficacy of lanreotide 30 mg as compared to placebo to relieve clinical symptoms due to small bowel obstruction in inoperable patients with peritoneal carcinomatosis.Secondary…

NEO-ADJUVANT RADIOTHERAPY-CHEMOTHERAPY IN STOMACH CANCER
Induction therapy with carboplatin, paclitaxel and radiotherapy in
patients with locally advanced gastric cancer

It seems logical that when the same treatment is applied before surgery, that patients will tolerate this easier. Analogous to rectal cancer it is assumed that by reducing tumor size, surgical outcome can be improved. In this preoperative approach,…

Efficacy and feasibility of the combination of everolimus and capecitabine in patients with metastatic or locally advanced pancreatic carcinoma

The primary objective of this study is to determine the efficacy and feasibility of the combination of everolimus and capecitabine in a group of patients with metastatic or locally advanced pancreatic cancer.

Generation of large-scale mature, monocyte-derived dendritic cells from adult cancer patients for the development of dendritic cell anti-cancer immunotherapy.

To validate the production of large-scale, total tumor RNA loaded, matured and functional DCs from periferal blood monocytes from patients with EAC and PC.

Value of PET-CT in Radiation Treatment Planning for Patients with Esophageal Cancer (RESPECT-study).

To determine the additional value of PET/CT in the radiotherapy treatment planning of patients with oesophageal cancer.The aim of this study will be to prospectively assess the impact of the application of PET in the radiotherapy treatment planning…

Neosquamous epithelium after radiofrequency ablation (RFA) of Barrett epithelium: Where does it come from?

Aims of this study are:1) To study the endoscopic and histological regeneration pattern of NSE after RFA of BE.2) To compare the histological and immunohistochemical characteristics of NSE to normal untreated squamous epithelium.3) To compare NSE,…

A phase I/ II, non-randomized, feasibility/ safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with metastatic pancreatic cancer

In this study we want to determine the activity and safety of concurrent interruption of the MAPK and PI3K pathways by EGFR and mTOR inhibition in patients with metatastatic pancreatic cancer

Preoperative short-term radiotherapy for primary resectable rectal cancer:
Accelerated once daily (5x5Gy)
versus
accelerated hyperfractionated twice daily (12x2,5Gy b.i.d.)
(ONCE-TWICE trial)
A phase II single-blinded multi-institutional randomised study

The objective of this prospective randomised trial is to test the hypothesis that hyperfractionated short course preoperative radiotherapy (12 x 2.5 Gy twice daily) leads to less radiation-induced bowel toxicity compared to the standard…

Phase I clinical study of the feasibility of pretargeted radioimmunotherapy of an anti-CEA bispecific antibody and Lu-177 labeled peptide in patients with advanced colorectal cancer

To determine the feasibility, toxicity and safety of anti-CEA x anti hapten bispecific antibodies (TF2) and Lu-177-labelled di-HSG-DOTA peptide (IMP-288) in patients with advanced colorectal carcinoma.

A Randomized, Double Blind, Placebo Controlled, Phase II Study Evaluating the Efficacy and Safety of RP101 in Combination with Gemcitabine Administered as First-Line Treatment to Subjects with Unresectable, Locally Advanced, or Metastatic Pancreatic Adenocarcinoma

Objectives:Primary Objective:* To compare the overall survival (OS) distributions of RP101 and gemcitabine to placebo and gemcitabine in subjects with unresectable, locally advanced or metastatic pancreatic adenocarcinomaSecondary Objectives:* To…

Feasibility study of external beam radiation therapy followed by high-dose rate endorectal brachytherapy (HDRBT) in inoperable rectal cancer patients

-To determine the feasibility and the maximum tolerated radiation dose in HDRBT of the rectum after EBRT in rectal cancer patients who are unfit for surgery or refuse surgery-To determine the incidence and severity of acute and late toxicity of EBRT…

A Randomized, Multicenter Phase 3 Study to Compare the Efficacy of Panitumumab in Combination with Chemotherapy to the Efficacy of Chemotherapy Alone in Patients with Previously Treated Metastatic Colorectal Cancer

The primary objective is to evaluate the treatment effect of P*mAb plus FOLFIRI on overall survival (OS) and progression-free survival (PFS) compared to FOLFIRI alone as second line therapy for metastatic colorectal cancer.

Enteral Nutritional strategies compared to reduce postoperative ileus after major colorectal surgery

The main objective of this clinical survey is to improve the nutritional status of patients undergoing major rectal surgery, thereby aiming to reduce postoperative ileus using the Bengmark a self-migrating nasojejunal tube and early enteral…

A randomized trial comparing radiofrequency ablation with step-wise radical endoscopic resection for treatment of Barrett*s esophagus with high-grade dysplasia or early cancer.

The purpose of this study is to find answers for the following questions:1. Is BARRX ablation a good alternative to step-wise radical endoscopic resection for patients with a Barrett*s esophagus with high-grade dysplasia or early cancer in terms of…

A double-blind, randomised, placebo controlled Phase III study of
nintedanib plus best supportive care (BSC) versus placebo plus BSC in
patients with colorectal cancer refractory to standard therapies.

The objective of this Phase III study is to evaluate the efficacy and safety of nintedanib in patients with mCRC after failure of previous treatment with standard chemotherapy and biological agents.

Palliation of Obstructive Local Disease of the Esophagus by Radiotherapy

The aim of this study is to compare the palliative effect of external beam radiotherapy with the palliative effect of intraluminal brachytherapy in the palliation of patients with obstruction of incurable oesophageal cancer. The outcome of the study…

A phase Ib/II, open-label, multi-center, dose escalation study of MEK162 in combination with panitumumab in adult patients with mutant RAS or wild-type RAS metastatic colorectal cancer

The aim of the phase Ib part is to estimate the MTD and/or identify the RP2D for the combination MEK162 and panitumumab, followed by a phase II part to assess the clinical efficacy and to further assess the safety of the combination in selected…