32 results
To identify pathogenic bacterial biofilms in UC-patients with and without neoplasia in tandem with host factors such as barrier defects and carcinogenic pathway activation in a prospective cohort study.
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
Primary Objective(s): 1. To obtain preliminary data on whether (and to which extend) adjuvant chemotherapy for colon cancer results in (a) deterioration of contractile muscle properties and increased muscle fatigability, (b) increased inflammation…
Brown adipose tissue activity and energy metabolism in cachexia induced by cancer or chronic disease
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…
To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.
To directly evaluate the gastric tube microcirculation with Dark Sidestream imaging during minimal invasive esophageal resection on several locations, i.e. from best arterial blood supply (antrum) to worst (fundus). Furthermore, to evaluate the…
The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…
The purpose of this study is to investigate the role of adipokines-secretion in visceral adipose tissue and its influence on the risk for esophageal adenocarcinoma. Examination of adipose tissue may provide important insight into mechanistic links…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
To determine the composition of immune cells and the expression of immunological factors in normal squamous esophagus, RE, BE and EAC.
To find procoagulant markers predictive of progression of the underlying malignancy or predictive of the occurrence of a venous thrombotic event.
The present study aims to investigate genetic factors that contribute to the development of BE.
Primary objective of the study is the assessment of the dose limiting toxicity (DLT) and the maximal tolerated dose (MTD) of capecitabine and mitomycin-C with concomitant SIBRT in patients with locally advanced anal carcinoma.Secondary objectives…
Is is possible to detect tumorcells in blood in patients with colon cancer with RT-q-PCR.
To determine which DC populations are present in esophageal tissue of patients with reflux esophagitis and BE. Relate the findings regarding DC populations to other pre-malignant gastrointestinal disorders (IBD).
Primary objective:To determine the relative risk of gastric cancer for genetic polymorphisms.Secondary objectives:- To determine the relative risk of gastric cancer for combinations of genetic polymorphisms, H. pylori virulence factors and lifestyle…
Primary Objectives:1. To compare the protein synthesis of pancreatic, liver, intestinal, fat and muscle tissue and leukocytes in cachectic patients.2. To compare pancreatic malignancy protein synthesis with the protein synthesis in normal pancreatic…
We aim to recognise potential genetic modifiers for mutations in PMS2. This will be approached through comparing a selection of CRC-related genes in the exome of members of a PMS2 family who differ in age of onset and severity of disease.