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Prone versus supine positioning for rectal cancer irradiation using volumetric modulated arc therapy

The primary aim of the study is to investigate the effect of patient positioning on OARs sparing in rectal cancer patients treated with VMAT (hypothesis 1). The secondary aim of the study is to investigate the possible differences in optimal patient…

The ARGOS project: Real-time assessment of Barrett neoplasia using computer aided detection. A pilot study

The aim of this pilot study is to interrogate the feasibility of the workflow, using this image-based CAD system real-time in the endoscopy suite.

Botulinum toxin (BOTOX®) to prevent post-operative pancreatic fistula in patients who undergo distal pancreatectomy. (PROFIT study)

This study has been transitioned to CTIS with ID 2024-517267-23-00 check the CTIS register for the current data. The aim of this research is to investigate whether it is feasible and safe to pre-operatively treat patients who will undergo a distal…

A PHASE 1, OPEN ­LABEL, SINGLE DOSE, 4­TREATMENT, PARALLEL GROUP STUDY TO EVALUATE THE EFFECT OF DIFFERENT MEAL REGIMENS AND THE EFFECT OF PROLONGED GASTRIC ACID SUPPRESSION BY RABEPRAZOLE ON THE RELATIVE ORAL BIOAVAILABILITY OF DERAZANTINIB IN HEALTHY MALE SUBJECTS

The purpose of this study is to investigate how quickly and to what extent derazantinib is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body. The pharmacokinetics of derazantinib when it is administered…

Catch the cancer;
towards a cfDNA-based test for colorectal cancer screening

The primary objective of the CATCA-study is to develop a cfDNA based screening/surveillance tool for colorectal adenoma and cancer, both in the setting of the national CRC screening program and in the surveillance of LS carriers. Additionally, we…

Optimalisation of exocrine pancreatic insufficiency and pancreatic enzyme replacement therapy.

Primary aim of this study is to validate easy and reliable tests to detect EPI in patients after gastrointestinal surgery. The 72-hour faecal fat quantification (gold standard), will be compared with a shortened version of 24-hours, the FET and 13C-…

Pretreatment upper-GI cancer organoid models for tailoring neoadjuvant treatment regimens

We aim to grow organoids from a large series of patients with gastric or esophageal cancer. The effect of the standard regimens of chemotherapy of radiotherapy is assessed on the organoids in vitro and correlated to the pathological response of the…

*Evaluating the feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy; a pilot study*

To explore feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy.

An open-label, randomised, phase III Study cOmparing trifLuridine/tipiracil (S 95005) in combination with bevacizumab to capecitabine in combination with bevacizumab in firST-line treatment of patients with metastatIC colorectal cancer who are not candidatE for intensive therapy

To demonstrate the superiority of S 95005 + bevacizumab over capecitabine + bevacizumab in terms of Progression-free survival (PFS) based on Investigator assessment in first-line treatment of patients with unresectable metastatic colorectal cancer…

Gut microbiome dynamics in metastasized or irresectable colorectal cancer: initiating a prospective multicenter cohort

To analyze the gut microbiome in relation to response and toxicity in a prospective cohort of patients with newly diagnosed metastasized or irresectable colorectal carcinoma treated with standard systemic therapy.

A combination of pre-screening for DPD deficiency by genotyping/phenotyping methods and pharmacokinetics-guided dosing of 5-FU for precision treatment to prevent severe toxicity in gastrointestinal cancer patients.

The primary objective of this study is to investigate the clearance of 5-FU for the 4 most common DPYD gene variants compared to the clearance of 5-FU in DPYD wild-type patients. The secondary objectives of this study are to determine the toxicity…

Multicenter, open-label, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody, for locally advanced or recurrent rectal cancer patients undergoing curative surgery.

This study has been transitioned to CTIS with ID 2024-510768-21-00 check the CTIS register for the current data. This study aims to investigate if fluorescence guided surgery performed with SGM-101 can improve R0 resection rates and allows to find…

Dedicated MR imaging vs surgical staging of peritoneal carcinomatosis in colorectal cancer patients; a randomized multicenter trial

Our goal is to perform a multicenter randomized study to compare a less invasive diagnostic workup ARM A (with MRI and surgical inspection reserved for borderline operable cases on MRI) to the standard diagnostic workup (ARM B, without MRI, with…

Phase 1b, Multicenter, Randomized, Blinded, Placebo-controlled Study to Evaluate the Efficacy of Guselkumab in Subjects with Familial Adenomatous Polyposis

To explore the effect of treatment with guselkumab in subjects with Familial Adenomatous Polyposis (FAP) on rectal/pouch polyp burden (the sum of the polyp diameters)

Validity and reproducibility of practical performance-based tests to estimate aerobic capacity in patients scheduled for elective colorectal surgery

We aim to determine the validity of the steep ramp test as practical performance-based aerobic capacity test in patients undergoing elective colorectal resection by correlating the tests* scores with the ventilatory anaerobic threshold and oxygen…

Multi-Interventional program for prevention and early Management of Anastomotic leakage
after total mesorectal excision in Rectal cancer patIents, IMARI-trial

To increase the one year anastomotic integrity rate in patients undergoing total mesorectal excision (TME) for rectal cancer by the routine and quality controlled implementation of a multi-interventional program, which includes:1. MBP with oral…

Imaging tumor angiogenesis using 18F-Fluciclatide PET/CT in patients with colorectal and pancreatic cancer.

Evaluating the feasibility of 18F-Fluciclatide PET/CT imaging of colorectal and pancreatic tumors.

A randomised Phase III feasibility study to compare radical TME surgery versus preoperative (chemo)radiotherapy and watchful waiting or local excision for treatment of early stage rectal cancer.

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Paravertebral catheter versus Epidural analgesia in Minimally Invasive Esophageal Resection: a randomized controlled multicenter trial (PEPMEN trial)

To compare paravertebral catheter versus epidural analgesia regarding the quality of recovery in patients undergoing minimally invasive esophagectomy.

Study on the effects of an OCT2/MATE1 substrate (metformin) and inhibitor (cimetidine) on the exposure of trifluridine/tipiracil (Lonsurf®) in patients with metastatic cancer.

To determine the influence of concomitant administration of Lonsurf with metformin and cimetidine on Lonsurf and metformin exposure.