23 results
The objective is to compare the efficacy and safety of masitinib 12 mg/kg/day to sinutinib 50 mg/day
The primary objective of this randomized clinical trial is to evaluate if perioperative SDD can reduce anastomotic leakage rate and other infectious complications while thereby simultaneously improving long-term oncological outcome. Secondary…
Phase I study to investigate safety of the combination indomethacin and two platinum-based chemotherapy regimens in patients with advanced cancers.
To investigate wether neo-adjuvant chemotherapy followed by cytoreductive syurgery and hyperthermic chemotherapy is feasible and reduces the number of irresectable patients with acceptable morbidity and mortality rates.
To compare the additional diagnostic yield obtained by using the PeerScope System* extended view vs. the diagnostic yield obtained by the Standard view colonoscopy.In addition, time measurements including time to cecum, time for withdrawal and…
PrimaryTo compare progression-free survival (PFS) between tivozanib in combination with mFOLFOX6 and bevacizumab in combination withmFOLFOX6 based on investigator radiological tumor assessmentSecondary• Progression Free Survival (PFS) based on…
This is a feasibility study of the Balloon-based Focal Cryoablation System to assess safety and performance in patients with a Barretts esophagus
The primary objectives are to determine the diagnostic performance of gadofosveset-enhanced T1-weighted MR imaging for the discrimination between pN0 and pN+ patients for both primary staging and restaging after chemoradiotherapy and to determine…
To compare a new endoscopic brush device with conventional brush cytology and compare the amount of cells obtained by the two different brushes
To compare a fully covered metal stent versus a partially covered metal stent in patients with dysphagia due to an incurable malignant stenosis of the esophagus or cardia.
To determine whether surgery induces changes in the liver vasculature of patients with colorectal cancer.
To identify circulating mediators that are released after surgery and which are responsible for macrophage activation.
Assessment of the detection of neoplastic lesions in patients with longstanding ulcerative colitis, using different endoscopic imaging techniques: A: Chromo-endoscopy, methylene blue 0.1% (HDTV Olympus)B: HDTV Olympus colonoscopes and NBIC: Chromo-…
Primary, to determine whether staining of the gastric mucosa increases the number of detected (pre)malignant foci of diffuse type gastric cancer, in individuals from families with FDGC as well as dysplastic, adenomatous and early intestinal cancers…
In patients undergoing surveillance endoscopy for Barrett;s oesophagus or work-up and treatment for early neoplasia in Barrett's oesophagus we will evaluate the N-Vision pVLE system for the following items:1) feasibility of the system2) the…
This clinical trial will evaluate the inter-observer agreement of a simple, consensus driven NBI classification system of surface patterns and its ability to differentiate dysplastic vs. non-dysplastic BE in patients undergoing BE screening or…
To investigate whether stem cell sparing radiotherapy results in a lower risk of dry-mouth syndrome than current standard treatment technique.
We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…
To develop an MR scanning protocol for pancreatic cancer
Primary objective: to investigate the intra- and interfraction motility of the CTV (the primary tumor as well as any affected celiac lymph nodes) in radiotherapy for esophageal cancer, and to determine adequate CTV-ITV margins.Secondary objective:…