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An exploratory, open label, single-arm study to evaluate the effect of Eligard® 6-month on biomarkers of disease in patients with metastatic prostate cancer

To explore the effect of Eligard® on the following prostate cancer biomarkers:• Testosterone in serum• Prostate Specific Antigen (PSA) in serum• Prostate Cancer Antigen (PCA3 score) in urine • PSA mRNA in blood/PBMC• PCA3 mRNA in blood/PBMC• TMPRSS2…

Diagnostic Accuracy of an Electronic Nose as Compared to Combined Conventional CT-Scanning, Autofluorescense Scopy for the Detection of Early Endobronchial Squamous Cell Cancer after prior History of Head-and-neck Cancer or Lung Cancer

To evaluate the value of volatile organic compounds analysis by eNose in the early detection of second primaries or metastasis (and early lesions).

ENUMERATION AND CHARACTERISATION OF CIRCULATING TUMOR CELLS (CTC) IN PATIENTS WITH SOLID MALIGNANCIES

To enumerate and characterize CTC in patients with solid malignancies before and, if applicable, after initiation of systemic treatment in order to improve the insight in the pathogenesis of metastases, and in mechanisms conferring resistance…

Fear of progression in advanced cancer patients with prolonged survival on ongoing cancer treatment in an era of personalized medicine

The aim of this study is to investigate the concept of fear of progression among advanced incurable cancer patients onongoing systemic treatment.

Online Measurement of Cognitive functioning in patients with cancers with CNS involvement

Primary Objective: To test the feasibility of online neuropsychological assessments using the Amsterdam Cognition Scan (ACS) compared to classical neuropsychological assessments in patients with cancers with CNS involvement.

Mapping the peritoneal immune system to identify novel immunomodulatory treatment options for diseases with peritoneal involvement.

AimThe MAPS study aims to unravel the immune composition of the human peritoneal cavity and the tumor immune environment in peritoneal metastasized gastric and colorectal cancer. The overarching aim is to find new targets for immunotherapy for this…

Longitudinal exploratory analysis of tumor-specific T-cell immunity and microbiome/calprotectin testing in patients with solid tumors

To study the effect of immune modulating therapies, including anti-CTLA4, anti-PD-1, anti-PD-L1checkpoint inhibitors, and TIL therapy, on the composition and activation of systemic and local immunity, with an emphasis on the size and diversity of…

The long-term impact of immunotherapy and targeted therapy on outcomes in patients with brain metastases

To determine outcomes in long-term surviving brain metastases patients (>=2 years after diagnosis of brain metastases) treated with immunotherapy or targeted therapy.

Determination of new biomarkers in patients with resectable colorectal liver metastases, the MIRACLE study

To establish (i) whether or not pre-operative determination of cell-free DNA (cfDNA) and circulating tumor cells (CTC), alone or in combination with each other, in peripheral blood of CRC patients with isolated colorectal liver metastases (CRLM)…

Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, open-label, single-arm, phase II study (CRC-PIPAC)

To prospectively explore the feasibility safety, tolerability, preliminary efficacy, costs, and pharmacokinetic profile of repetitive ePIPAC-OX as a palliative monotherapy for isolated unresectable colorectal PM under controlled circumstances.