211 results
To optimise, test and evaluate new and modified MRI sequences and technology under a test-retest scheme. To validate new sequences in patients in order to reduce MRI protocols in the future.
To assess uptake of 11C-osimertinib in tumor lesions of T790M double positive patients and T790M double negative patients, thereby evaluating specific and aspecific (off-target) 11C-osimertinib accumulation in tumor tissue.
The PRE-FURTHER project aims to evaluate the feasibility of the combined EBRT and MR-HIFU treatment for relief of metastatic bone pain, and to optimize the combined treatment logistics.
Primary study aim:To determine the efficacy, in terms of the meadian progression-free survival, in patients with recurrent or metastatic endometrial cancer (including carcinosarcoma of the endometrium) receiving treatment with durvalumab and…
To investigate the impact of intra-arterial administration of 177Lu-dotatate on the intrahepatic biodistribution in patients with NET liver metastases. Our primary objective is to to evaluate if there is a difference in post-treatment tumor-to-non-…
Radiolabeled bevacizumab as a tracer of VEGF expression in patients with colorectal liver metastases
Evaluation of tumor localization of In-111 labeled bevacizumab and possible correlation with VEGF expression in patients with colorectal liver metastases.
This study has been transitioned to CTIS with ID 2023-507263-19-00 check the CTIS register for the current data. To compare the efficacy of MRTX849 versus docetaxel in patients with NSCLC with KRAS G12C mutation and who have received prior treatment…
This study has been transitioned to CTIS with ID 2023-504709-35-00 check the CTIS register for the current data. This is a first-in-human Phase Ia/Ib, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability,…
This study has been transitioned to CTIS with ID 2024-518171-59-00 check the CTIS register for the current data. To determine if the use of Prostate-Specific Membrane Antigen Positron Emission Computer Tomography (PSMA PET/CT) as a selection tool…
Primary objective: To assess feasability of DMI for intrahepatic tumor detection. Secondary objectives: - Head-to-head comparison between DMI and FDG-PET/CT for intrahepatic tumor detection.- Assessment of requirements for spatial resolution and…
To assess the objective response rate (ORR), progression free survival (PFS), overall survival (OS), duration of response (DoR), toxicity, and quality of life (QoL) of patients with advanced SGC treated with cabozantinib in 3 cohorts: salivary duct…
The aim of this study is to develop and validate the ELISA and potential other assays (e.g. LC-MS), in order to measure drug concentration levels. For this, blood and other material will be collected.
To determine local control of SBRT treatment for abdominopelvic oligometastasis based on a fractionation scheme of 45 Gy in 5 fractions, to evaluate local control, survival and toxicity. Use of the plan of the day as a tool for optimize tumor…
The aim is to determine the effectiveness of adjuvant HIPEC using oxaliplatin following a curative resection of a pT4 or intra-abdominally perforated colon cancer in preventing the development of PC in comparison to the standard adjuvant systemic…
To determine if SRS is a better palliative treatment than WBRT for patients with 4 up to 10 BM in terms of QOL at 3 months post-radiotherapy.
Primary objectivesPhase I:To determine the recommended phase 2 dose (RP2D) of the dacomitinib-PD-0325901 combination in patients with KRASm NSCLC Phase II:To determine the progression free survival of the dacomitinib/PD-0325901 combination compared…
To investigate whether tPRF has an effect on the specific tumor marker of a specific tumor type in a patient with advanced cancer.
Primary objectives: To assess the feasibility, accuracy and safety of preoperative SPECT/CT and intraoperative fluorescence imaging after administration of 111In-labetuzumab-IRDye800CW in patients with PC of colorectal origin who will undergo…
Primary ObjectiveThe primary objective is to assess safety and tolerability, describe the dose limiting toxicities (DLTs), and determine the maximum tolerated dose (MTD) or the maximum administered dose (MAD; in the absence of exceeding the MTD) for…
To validate the use of 3 and 7 Tesla nano-MRI in restaging locally advanced rectal cancer by node-to-node matching of the results of nano-MRI with pathology as the gold standard.