60 results
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
• Determine the impact of variations in multi-parametric MRI on the prediction of tumor probability
To test the feasibility of translating recent technological advances in MRSI of prostate cancer at 7T to the regular 3T platform to improve the capacity to separate partially overlapping peaks of polyamines from choline and creatine
In this proposed study, we aim to test not only the safety and biodistribution of [68Ga]Sarabesin 3, but also its potential to visualise prostate cancer. If the peptide proves to be successful, a next study will be initiated to test the potential to…
The primary objective of this study is to compare HistoScanningTM guided prostate biopsy with systematic biopsy in the detection of prostate cancer in men candidate for a first or second biopsy procedure.
To obtain data, images and feedback from the initial clinical use of investigational four channel output eCoils designed for Siemens 1.5T and 3.0T scanners compared to the current, commercially available single channel eCoils for these field…
To investigate whether laparoscopy is cost-effective in predicting which patients will benefit from primary surgery and which patients should be treated with neoadjuvant chemotherapy and interval surgery instead.
The primary aim of this pilot study is to determine whether CTCs are a reliable predictor of survival in men with CRPC receiving docetaxel-based chemotherapy by using the Veridex CellSearch system and the biomarkers PCA3, TMPRSS2-ERG and biomarker…
Influence of Injection time of DCE-MRI for prostate cancer patients with consistent kinetic parameters.
Our goals are to collect blood from men randomized to the intervention arm of the Dutch part of the European Randomised study of Screening for Prostate Cancer (ERSPC) and actually screened (www.erspc.org, N=19.970, METC 138.741/1994/152). With the…
1. To what extend does hypoxia occur in cervical cancer and what is the intra- and intertumor heterogeneity?2. To what extend does proliferation occur in cervical cancer and what is the intra- and intertumor heterogeneity?3. Does co-localization of…
This is a pilotstudy after characterising prostate tissue by using DCE-MRI in patients with a localised prostate cancer.The relation between DCE-MRI and vasculature and oxygenation will be investigated as a preparation for further studies.
1. Compare generic and pelvic-floor-specific QOL in patients who have been treated or gynaecologic cancer to that of patients without cancer attending a gynaecologist for pelvic floor symptoms.2. Examine how many and which patients receive or have…
Confirm the interaction between colchicine and the choline pathway as seen with FCH-PET.
The purpose of our study is to prospectively establish in vivo in patients proof of principle for the RUNMC MR imaging-compatible robotic system designed for image-guided prostatic needle intervention.
The primary objectives of our study are: - Determining the long-term predictive value of a positive HPV test for (pre)malignant cervical disease.- Determining the long-term protective value of a negative HPV test. - Determining the long-term…
To investigate whether advanced-stage prostate cancer patients have circulating prostate (cancer)-specific CD8+ T-lymphocytes
The primary objective is to determine the positive and negative predictive value of an hrHPV test after treatment for the development of recurrent (cervical) disease on the long term.
To test a near-infrared fluorescence camerasystem in order to detect folate-FITC in tumour tissue in women with ovarian cancer who undergo cytoreductive surgery.
To test an intra-operative fluorescent camera system with a fluorescent optical agent in detection of the sentinel lymph node. This will be compared to the standard method with radiocolloid and patent blue.