12 results
To evaluate the duration of admission, feasibility, patient satisfaction and complication rate of vNOTES hysterectomy with BSO and compare it with laparoscopic hysterectomy with BSO in case of clinical stage 1 low grade endometrial cancer.
The primary objective of this study is to develop an diagnostic algorithm using ct-DNA, and TEPs as liquid biomarkers in combination with the existing ultrasound models (RMI and IOTA-models) and biomarkers (CA125 and HE4) to differentiate between…
Primary objective:- To determine if TTFields at 200 kHz to the abdomen and pelvis with weekly paclitaxel in the treatment of recurrent ovarian cancer patients prolongs the overall survival of patients, compared to weekly paclitaxel treatment alone.…
The purpose of the study is to determine whether treatment with alpelisib in combination with olaparib can delay the time to cancer progression compared to standard-of-care chemotherapy in participants with your type of ovarian cancer known as…
This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…
This study has been transitioned to CTIS with ID 2024-511966-36-00 check the CTIS register for the current data. To evaluate the bilateral SLN detection rate of intraoperative ICG with NIR fluorescence imaging compared to the current standard of…
Primary objectives: To optimize ex vivo testing procedures for cervical cancer patients derived tumor tissue tumoroids culturing from tissue from the primary tumor.To evaluate the success rate of ex vivo drug sensitivity testing for cervical cancer…
This study has been transitioned to CTIS with ID 2023-503267-42-00 check the CTIS register for the current data. Primary:• 3 year recurrence free survival (RFS), in patients with MMRd HREC Secondary:• RFS (median and at 5 years)• OS (median, 3yr,…
We expect the BMI and the type of fat distribution to have a significant influence on the change in hormone levels, fat metabolism and systemic inflammation levels after bilateral salpingo-oophorectomy (BSO). In patients with endometrial cancer,…
Primary objective:- To determine the difference in mean dose (Gy) to pelvic bones (whole pelvic contour), and the difference in the mean V15Gy-bowelbag volume in cc (according to EMBRACE bowel bag definition) between photon and proton therapy in…
The primary objective of the study is to estimate the clinical benefit of cemiplimab + ISA101b after progression on first line chemotherapy, as assessed by objective response rate (ORR).The secondary objectives of the study are:• To characterize the…
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…