67 results
In the future, the determination of CTCs and ctDNA in the CSF could be a new quantitative method for the anti-tumor response assessment of systemic or intrathecal therapy (as opposed to CSF cytology, which is subjective and not a quantitative method…
Primary ObjectiveTo investigate whether ultrasound guided tumor resection succeeds gross total resection significantly more frequently, when compared with the conventional non-ultrasound guided tumor resection.Secondary Objective(s)To investigate…
This study compares iMRI with cNN for the primary endpoint (percentage of residual tumor volume) and the secondary endpoints (complications, clinical functioning / quality of life, and survival).
this study aims to evaluate the clinical value of ASL in the clinical MRI protocol of children with a brain tumor. To serve the sample size calculation, its primary objective is to assess whether there is a correlation between perfusion of (parts of…
Determining VEGF expression in pHGG and DIPG using 89Zr-Bevacizumab
The aim of this pilot study is to obtain datasets that can be used to optimize high-resolution CTP and compare image quality to current standard techniques such as standard CTP and MR perfusion imaging (T2*-weighted DSC-MRI) in a group of patients…
1. Protocol A: Laser Speckle Imaging (LSI) of blood flow changes coupled to neuronal activity in the human cerebral cortex: To investigate and optimize the use of LSI to visualize blood flow changes coupled to neuronal activity. The aim is to…
The objective of this study is to acquire a set of images and associated technical information to facilitate regulatory submission of the pulse sequences
This study wants to evaluate on intraoperative MRI whether contrast enhancement at the borders of the resection cavity correlates with tumor tissue, and whether no contrast enhancement correlates with the absence of tumor tissue. To differentiate…
The goal of this study is to improve risk stratification and treatment allocation for medium and high risk neuroblastoma patients by real time quantitative (RQ)- PCR-minimal residual disease (MRD) testing.We have recently developed a panel of RQ-PCR…
To determine the localisation within the primary tumor of the therapy resistant cells, before and during radiotherapy to determine the accurate boost volume. To determine changes during treatment intra- and extratumoral within the irradiated area.(…
The main objective of the study is to compare the diagnostic power of Magnetic Resonance Spectroscopy, Fluorothymidine Positron Emission Tomography and conventional MRI in measuring the response of glioblastoma to radiotherapy and chemotherapy.The…
The aim of this study if PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of concomitant radio/chemotherapy for patients with newly diagnosed GBM is superior to MRI at 10 weeks to evaluate treatment response and to…
To determine the effect of SRT on cognition and on quality of life of patients with one to 3 brain metastases, and to relate these outcome measures with radiological changes detected on MR imaging.
This study is designed (1) to validate white matter tracts derived from DTI-FT with the results of ioESM, and (2) to develop RSFC analysis in order to quantify changes in functional connectivity patterns in patients that recover from neurosurgery-…
The primary objective of this clinical pilot study is to explore the feasibility of Flatpanel Detector - Parenchymal Blood Volume (FD-PBV) imaging in patients with intracranial meningiomas during neurosurgery in the Hybrid-OR. Image quality, added…
The main objective of this study is to further validate our fUS-technique by comparing and contrasting the spatial and temporal patterns of fUS-defined functional areas with results acquired using fMRI in the same human subject.
Primary Objective: To assess whether both OCT (optical coherence tomography) and/or HSI (hyperspectral imaging) detect differences in glioma tissue as compared to healthy tissue as examined during brain-surgery.Secondary Objective(s): To assess if…
Primary objective* To evaluate the efficacy in terms of overall survival (OS) of erlotinib, everolimus and dasatinib in combination with radiation therapy, in patients with a DIPG both: - compared to the other experimental treatments by comparisons…
Implementation of liquid biopsy by NGS in cell-free circulating tumor DNA in CSF and / or blood, in patients clinically suspected of leptomeningeal metastases and / or brain metastasesDemonstrate that the detection of additional tumor mutations in…