71 results
1) Evaluating the effect and recovery of glioma surgery in eloquent areas on cognitive functioning.2) Examining the effec tof glioma surgery in eloquent areas on quality of life.3) Examining the effect of gliomas in eloquent areas on the…
A pilot study of the feasibility of 11C-MET as postoperative baseline scan in the follow-up of high-grade gliomas for the detection of tumor recurrence.
Primary Objective: To assess whether both OCT (optical coherence tomography) and/or HSI (hyperspectral imaging) detect differences in glioma tissue as compared to healthy tissue as examined during brain-surgery.Secondary Objective(s): To assess if…
Primary objective: to non-invasively characterize the IDH1-mutational status of gliomas in patients by measuring the ratio of GPC/PE with 31P MRSI and 2HG content by 1H MRSI in the same examination. This is expected to make the identification of the…
Primary objective* to determine GTV in patients with an untreated GBM with 7T MRI without contrast-enhancement.Secondary objective* to compare the GTV as created based on 7T MRI to the GTV based on 3T MRI.* to determine the clinical target volume (…
Determining VEGF expression in pHGG and DIPG using 89Zr-Bevacizumab
The aim of this pilot study is to obtain datasets that can be used to optimize high-resolution CTP and compare image quality to current standard techniques such as standard CTP and MR perfusion imaging (T2*-weighted DSC-MRI) in a group of patients…
The aim of this study is to understand what it means to be anxious for adults with a malignant glioma. This study focuses on the lived experience and the underlying processes of the meaning of anxiety.Main question: "What does it mean for…
1. Protocol A: Laser Speckle Imaging (LSI) of blood flow changes coupled to neuronal activity in the human cerebral cortex: To investigate and optimize the use of LSI to visualize blood flow changes coupled to neuronal activity. The aim is to…
This study compares iMRI with cNN for the primary endpoint (percentage of residual tumor volume) and the secondary endpoints (complications, clinical functioning / quality of life, and survival).
this study aims to evaluate the clinical value of ASL in the clinical MRI protocol of children with a brain tumor. To serve the sample size calculation, its primary objective is to assess whether there is a correlation between perfusion of (parts of…
The aim of this study if PET using [18F] fluorothymidine (FLT), an imaging biomarker, performed at week 10 of concomitant radio/chemotherapy for patients with newly diagnosed GBM is superior to MRI at 10 weeks to evaluate treatment response and to…
The objective of this study is to acquire a set of images and associated technical information to facilitate regulatory submission of the pulse sequences
This study wants to evaluate on intraoperative MRI whether contrast enhancement at the borders of the resection cavity correlates with tumor tissue, and whether no contrast enhancement correlates with the absence of tumor tissue. To differentiate…
This research aims to improve quality of life of patients with high grade glioma. Psychological variables which determine quality of life in this group will be determined. By means of collecting data on several questionnaires about concerns of this…
This study is designed (1) to validate white matter tracts derived from DTI-FT with the results of ioESM, and (2) to develop RSFC analysis in order to quantify changes in functional connectivity patterns in patients that recover from neurosurgery-…
The main objective of the study is to compare the diagnostic power of Magnetic Resonance Spectroscopy, Fluorothymidine Positron Emission Tomography and conventional MRI in measuring the response of glioblastoma to radiotherapy and chemotherapy.The…
To determine the effect of SRT on cognition and on quality of life of patients with one to 3 brain metastases, and to relate these outcome measures with radiological changes detected on MR imaging.
To determine the localisation within the primary tumor of the therapy resistant cells, before and during radiotherapy to determine the accurate boost volume. To determine changes during treatment intra- and extratumoral within the irradiated area.(…
Exploring and documenting the end-of-life phase in HGG patients: duration; residence (at home, nursing home, hospice, hospital); transfers between care settings, medical problems; palliative treatment/care; end-of-life decisions and cause of death…