125 results
The current study is designed to test the hypothesis that the medulla in transplanted kidneys is still hypoxic at 1 day after transplantation using a non-invasive method: BOLD MRI.By studying two groups a comparison can be made between patients…
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.
First, to determine the extent to which oxidative stress and microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular…
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
the study aims to answer the following question:are components of innate immunity in general, and the complementsystem in particular, correlated with and usefull as predictors for the occurrence of macro- and/or microvascular complications in a high…
The purpose of this study is to determine if the development of idiopathic scoliosis is related to neuropathic detrusor/sphincter dyssynergia. When bladder and sphincter function are disturbed, adequate therapy can be started in an early phase to…
Our primary objective is to investigate if the previously found MSNA is related to the presence and severity of CV organ damage quantified as left ventricular mass, independent of other CV risk factors. We hypothesize that despite of treatment…
What is the prevalence of ASB and incidence of UTIs during pregnancy in women with DM or GDM compared to pregnant women without diabetes? In addition, risk factors for ASB and UTIs, as well as consequences of ASB and UTIs will be investigated. These…
With this pilot study we want to see if there are measurable differences in body composition after one year. In what way does the body composition of patients change during the first year after transition from CHD to NHHD or NCHD? Is the weight gain…
This study evaluates glomerular function in children with a solitary functioning kidney. Furthermore anthropometric data is gathered about waist-hip ratio and subscapular skinfold thickness. Anthropometric characteristics can be both a cause as an…
The objective of this study is to proof the presence of lesions in the brain of patients with overactive bladder and urge-incontinence (OAB wet) as a central cause of this disorder. This survey is a pilot investigation for a larger study on the…
Objective of this study is to map the possible differences in immunostatus between a urethra in patients with a Hautmann neobladder and a normal urethra in patients without (a history of urogenital) malignancy; to find clues for the decreased risk…
The major aim of this project is to elucidate the molecular basis of IgAN. A large cohort of IgAN patients will be screened on aberrancies in the DNA sequence or expression of the gene encoding Cosmc, a protein that is essential for the biosynthesis…
Establish relevance of a clinical scoring system, and of established and to be identified biomarkers in blood and urine for clinical course and clinical and microbiological outcome of patients with a complicated urinary tract infection, treated in…
The primary aim of this study will be to determine the effect of rosiglitazone on intima media thickness and calcification in patients with stage 4 and 5 CKD. The secondary end points are the effects on pulse wave velocity, blood pressure, the lipid…
Our primary objective is to investigate the role of connective tissue growth factor (CTGF, a downstream mediator of profibrotic TGF-β1 activity) in peritoneal fibrosis and EPS. We hypothesize that soluble levels of CTGF and CTGF expression in the…
To determine the vitamin K status in children with chronic renal failure (peritoneal dialysis patients, hemodialysis patients) and evaluate whether a correlation between bone and vascular parameters and vitamin K status exists. If vitamin K status…
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
The main goal of the study is evaluation of the effects from renal artery stenosis on intrarenal flow-distribution and tubular function. Assumed and measured effects are alterations of medullary flow, inflammatory markers and overall tubular…