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A phase I, open-label trial to investigate metabolism, pharmacokinetics (following a mass balance design) and absolute bioavailability of BI 690517 (C-14) after oral and intravenous administration in healthy male subjects

The purpose of this study is to investigate how quickly and to which extent the new study compound BI 690517 is absorbed, transported,and eliminated from the body. BI 690517 is an investigational study compound which has not yet been approved for…

Generation of urothelial cancer organoids to investigate tumor biology in organoids and to perform drug sensitivity testing.

Primary objective:To establish and propagate a bladder cancer / immune cell co-culture model to study patient response to immunotherapy ex vivo. (Can organoid and immune cell co-cultures be maintained for 3 passages?) Protocols will be improved…

Effect of dapaglifozin on serum magnesium in HNF1β patients with renal hypomagnesemia

This study has been transitioned to CTIS with ID 2024-518855-43-00 check the CTIS register for the current data. Primary objective: To evaluate the effect of SGLT2 inhibition with dapagliflozin 10 mg on serum magnesium in diabetic and non-diabetic…

Functional MRI and Doppler ultrasound of living kidney donors and recipients: a longitudinal trajectory from donor to recipient

Through the utilization of fMRI and DUS we aim to illustrate the physiological change a kidney graft undergoes during a transplantation trajectory from donor to recipient. Secondarily, we intend to establish a baseline reference for normal…

Alkaline Phosphatase as treatment of Ischemia Reperfusion Injury to prevent delayed graft function in deceased donor kidney transplantation

This study has been transitioned to CTIS with ID 2024-515480-66-01 check the CTIS register for the current data. To attenuate the impact and duration of delayed graft funtion by dampening schemia reperfusion injury

DAPARHT: DAPAgliflozin for Renal protection in Heart Transplant recipients

The DAPARHT trial is designed to assess effect of the SGLT2 inhibitor dapagliflozin to prevent deteriorating renal function in heart transplant recipients. Secondary objectives are to assess the impact of treatment on: i) weight, ii) glucose…

Dietary oxalate absorption and microbiome diversity in patients with nephrolithiasis and hyperoxaluria: a stable isotope technique.

With this study, we aim to gain insight in the influence of dietary oxalate on urinary oxalate levels by quantification of the intestinal oxalate absorption in patients with recurrent idiopathic calcium oxalate stones, primary hyperoxaluria, and…

Self-management as a first-line treatment prior to GP consultation for men with lower urinary tract symptoms

To assess the effectiveness and cost-effectiveness of providing an online personalized self-management program as a first-lineintervention to men with lower urinary tract symptoms (LUTS) compared to care as usual (CAU).

StoMakker: Improving the quality of life of children receiving an ileostomy, colostomy or continent urostomy by offering access to a peer support platform, age dependent information provision and games in a smartphone application

The main objective of this study is to investigate whether access to a peer support platform, age-dependent information provision and games in a smartphone application increases self-reported quality of life, for children receiving a stoma.

A Phase 3, Open-Label, Multi-Center, Randomized Study Evaluating the Efficacy and Safety of TAR-200 in Combination with Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants with BCG-naïve High-Risk Non-Muscle Invasive Bladder Cancer (HR-NMIBC)

This study has been transitioned to CTIS with ID 2023-507187-39-00 check the CTIS register for the current data. The purpose of this study is to compare event-free survival (EFS) in participants with Bacillus Calmette-Guerin (BCG)-naive high-risk…

Evaluation of the additional effect of continuous ultrasound bladder monitoring in urotherapy for children with functional daytime urinary incontinence. The SENS-U trial

To evaluate cost effectiviness of the SENS-U (continuous ultrasonic bladder monitoring) in urotherapy for children with functional daytime urinary incontinence.

An 18-month, open-label, single-arm safety extension study of an age-and bodyweight-adjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children and young adults from 1 to 18 years of age with chronic kidney disease and proteinuria

This study has been transitioned to CTIS with ID 2023-504885-50-00 check the CTIS register for the current data. A study to learn more about how safe the study treatment finerenone is inlong-term use when taken with an ACE inhibitor or angiotensin…

A controlled, open-label post-authorisation efficacy and safety study in imlifidase desensitised kidney transplant patients with positive crossmatch against a deceased donor prior to imlifidase treatment, including non-comparative registry and concurrent reference cohorts

This study has been transitioned to CTIS with ID 2024-511810-18-00 check the CTIS register for the current data. Primary objective• To determine the 1-year graft failure-free survival in highly sensitised kidney transplant patients, pre-treated with…

The influence of sacral neuromodulation on brain areas involved in the sensation of bladder filling in patients with Overactive Bladder (OAB) using fMRI

2.1 Primary Objectives• To identify brain activation evoked by sensation in response to bladder filling in patients with an implanted sacral neurostimulator as a treatment for overactive bladder (OAB), compared to a baseline in OAB patients without…

Long-Term Follow-Up of Patients who have received an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in a prior clinical study.

This study has been transitioned to CTIS with ID 2024-512580-31-00 check the CTIS register for the current data. PrimaryTo evaluate the long-term safety and tolerability of TX200-TR101 up to 15 years post-TX200-TR101 infusion/baseline.SecondaryTo…

Protein supplementation and exercise training to increase muscle protein synthesis rates in patients with advanced chronic kidney disease

1. To assess whether the skeletal muscle protein fractional synthesis rate as measured by the deuterated water method is different during a 1-week habitual lifestyle period when compared to a 1-week period with resistance-type exercise and protein…

The RENAL LIFECYCLE trial: A Randomized Controlled Clinical Trial to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients with Severe Chronic Kidney Disease

This study has been transitioned to CTIS with ID 2023-508389-13-00 check the CTIS register for the current data. To determine whether dapagliflozin is superior to placebo in reducing the incidence of the primary composite endpoint of kidney failure…

Safely reduce cystoscopic evaluations for microscopic Hematuria patients (SeARCH Trial).

To assess the clinical impact of implementing a molecular urine test in the diagnostic workup of patients presenting with microscopic hematuria.

A phase 2/3 Adaptive, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease

• To evaluate the efficacy of VX-147 to reduce proteinuria• To evaluate the efficacy of VX 147 on renal function as measured by eGFR slope

An interventional, non-invasive, monocentric study to evaluate the safety and performance of the wearable ultrasound bladder sensor (SENSA) in adult patients with urinary incontinence problems

Primary objectiveDemonstrate that the SENSA Bladder Sensor can detect the bladder before urination among its adult intended user Secondary objective(s)1) Collect real-life data to evaluate the clinical performance of the SENSA Bladder Sensor, the…