183 results
Primary: * To assess the change baseline in 24-hr proteinuria with dapagliflozin for six weeks relative to placebo treatment in patients with non-diabetic kidney disease and proteinuria > 500 mg/day on stable ACEi or ARB treatment. Secondary…
Overall aim: Given the aforementioned rationale it is therefore important to know the natural course of the disease and stage specific morbidity and mortality factors in a longitudinal observational study, to evaluate the levels of and associations…
- to explore the decline in renal concentration ability (RCA) in a Dutch population of lithium treated patient - to explore the decline in kidney function
PRIMARY OBJECTIVE:To assess the safety and tolerability of MOR202 treatment in subjects with aMNKEY SECONDARY OBJECTIVE:To assess the effect of MOR202 on serum anti-PLA2R antibodies in subjects with aMNSECONDARY OBJECTIVES:1. To assess…
This study has been transitioned to CTIS with ID 2023-503382-29-00 check the CTIS register for the current data. * Evaluate the effect of lumasiran on plasma oxalate in patients who are not on dialysis therapy Cohort B* Evaluate the effect of…
This study has been transitioned to CTIS with ID 2023-509343-27-00 check the CTIS register for the current data. Participants enrolling from study CLNP023B12301 or CLNP023B12302• Primary Objective: To evaluate the long-term safety and tolerability…
This study has been transitioned to CTIS with ID 2023-508690-92-00 check the CTIS register for the current data. The primary objective is to evaluate the long-term safety and tolerability of iptacopan in eligible participants. The primary clinical…
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…
To clarify the mechanism of azoospermia in male cystinosis patientsTo determine the cause of azoospermia in male cystinosis patients as obstructive or non-obstructive by non-invasive means (clinical examination, reproductive hormonal profile,…
To investigate whether it is possible to indicate (focal) IF/TA lesions in renal allografts with MRI and compare these findings to the extent of IF/TA in the kidney biopsy that has been taken previously according to current clinical guidelines.
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
The aim of this trial is to study if physical performance improves and protein energy wasting decreases in patients who change from conventional hemodialysis to nocturnal hemodialysis, compared to patients who continue their treatment on…
The effect of correction of metabolic acidosis in chronic kidney disease on intrarenal RAS activity.
Primary Objective: - To study if sodiumbicarbonate therapy in patients with metabolic acidosis due to chronic kidney disease diminishes intrarenal RAS activity (without affecting the systemic RAS).Secondary Objective(s): - To study if…
To compare the antiproteinuric effects of sacubitril/valsartan (ARNI) and valsartan (ARB).
The specific objectives of the SCOPE project will be:O1. to assess existing methodologies for CKD screening among older adults using real-life data from a cohort of 75+ older patients; O2. to investigate novel and potentially useful application of…
Primary Objective:* To demonstrate the safety of intravenous (i.v.) iodinated iso-osmolar iodixanol (Visipaque* Injection 320 mgI/mL) usage in contrast-enhanced computed tomography (CECT) for CKD stage III/IV patients by evaluating the incidence of…
Primary objective is to design a non-invasive, bedside monitoring strategy for early detection of renal graft hypoperfusion after pediatric kidney transplantation, using transabdominal ultrasonography and biomarker surveillance in serum and urine.…
In this pilot study, we aim to validate MR-measurement of GFR to gold standard clearance measurements in subjects with a range of different GFRs: namely chronic kidney disease (CKD) patients, hypertensive patients and healthy subjects.
are sildenafil, metformin and simvastatin effective in stimulation of ADH independent urine concentration in man?