50 results
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
The main goal of the study is evaluation of the effects from renal artery stenosis on intrarenal flow-distribution and tubular function. Assumed and measured effects are alterations of medullary flow, inflammatory markers and overall tubular…
to develop standardized tubular function tests with reference intervals/values.
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
The main goal of the current study is to confirm the origin of this sympathetic signal and compare it to the response in healthy humans. Secondly the goal is to assess the extent to which the suggested renal pressor response in CKD can be reversed.
To measure changes in urinary RAS components during an acid-loading test in patients with CKD and healthy controls.
to determine if there is an alternative mechanism for urine acidification in men in response to furosemide other than that through ENaC
The objective of this study is to investigate the role of inflammatory mediators (circulating platelet activity levels, MP numbers, and levels of plasma/urinary mtDNA) to the occurrence and severity of acute rejection and renal outcome.
1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
Development of a predictive test for r-FSGS at the individual level of a patient and kidney donor with FSGS.
We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.
Objectives: 1. To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional…
To compare salt taste and saliva characteristics in healthy volunteers and patients with CKD.
To evaluate the prevalence of C-TMA in patients presenting with TMA, either with coexisting conditions or not. Furthermore, (i) the diagnostic performance of an in-house developed ex vivo test, (ii) dynamics of complement measures during follow-up,…
To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.
This study has been transitioned to CTIS with ID 2024-517467-23-00 check the CTIS register for the current data. Primary objective: - To investigate the effect of additional levamisole in comparison with placebo from 4 weeks to 6 months after the…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…
To accomplish this aim we will address the following objectives:1. Define kidney disease heterogeneity within and between families carrying heterozygous COL4A3/COL4A4 pathogenic variants and evaluate hearing loss as non-renal phenotype;2. Analyze…
The primary objective is to determine whether iRVF patterns and renal damage/function are different in patients with a Fontan circulation compared to age and sex-matched healthy controls.The secondary objectives are to- Identify the prevalence of…