252 results
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
The main goal of the study is evaluation of the effects from renal artery stenosis on intrarenal flow-distribution and tubular function. Assumed and measured effects are alterations of medullary flow, inflammatory markers and overall tubular…
To compare the efficacy of tolvaptan treatment in reducing the change in estimated glomerular filtration rate (eGFR) from pre-treatment baseline to post-treatment followup, as compared with placebo, in subjects with late-stage chronic kidney disease…
Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…
1. to determine the feasibility and acceptability of an e-supported lifestyle coaching program and2. to assess the effects of personalized lifestyle support in patients with insulin dependent type 2 diabetes mellitus immediately after 12 weeks and…
Objective of this study is to compare 1-year garft survival after hypothemic machine perfusion with oxygentaed perfusion solution versus static cold storage of extended criteria kidneys from DBD donors.
to develop standardized tubular function tests with reference intervals/values.
Primary Objective:To evaluate the efficacy of ASP8232 in reducing Urinary Albumin Creatinine Ratio (UACR) in subjects with Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) at 12 weeks compared to placebo.Secundary Objectives:1. To…
The study has 3 objectives: 1. Proving that this form of RCA does not increase the risk of bleeding while achieving a degree of anticoagulation of the extracorporeal system that is similar to that when using LMWH. When this study shows that citrate…
Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the DPP-4i linagliptin versus the SU derivative glimepiride on fasting and postprandial renal hemodynamics (glomerular filtration rate (GFR)/ effective renal…
To study the efficacy, adverse events, logistic feasibility and costs of immunoadsorption for the removal of anti-GBM antibodies in patients with acute renal failure due to anti-GBM glomerulonephritis.
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
The main goal of the current study is to confirm the origin of this sympathetic signal and compare it to the response in healthy humans. Secondly the goal is to assess the extent to which the suggested renal pressor response in CKD can be reversed.
To assess intra- and interpatient variability of plasma Mg concentration before and after hemodialysis.
To measure changes in urinary RAS components during an acid-loading test in patients with CKD and healthy controls.
Collect data in an observational study on outcomes of endovascular fistula creation using the everlinQ endoAVF System
to determine the normal FGF23 response in case of hypophosphatemia
to determine if there is an alternative mechanism for urine acidification in men in response to furosemide other than that through ENaC
Primary Objectives: 1. To assess the prevalence of AAV related damage in AAV, i.e. cardiovascular damage and impaired QOL.Secondary objectives2. To assess whether there exists an association between cardiovascular disease, QOL and disease activity…
to determine the prevalence and significance of chronic nephrotoxic effects of cisplatin therapy by 1) identifying patients with chronic cisplatin nephrotoxicity and 2) reviewing their QoL. Eventually, this could improve care in these patients