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To evaluate the long-term safety and efficacy of two concentration-controlled everolimus regimen in de novo liver transplant recipients at Month 36 post-transplantation.
Study the clearance of immunoglobulin free light chains by HDF, lf-HD and high flux hemodialysis (hf-HD) using polysulphone and polyamide dialyzers.
Based on the hypothesis that hemodialysis with Hemocontol is associated with a greater and earlier increase in plasma vasopressin levels than standard dialysis, we examine whether there is a difference in the course of plasma vasopressin levels…
Objective: To investigate the safety and efficacy of a therapy consisting Everolimus and corticosteroids maintenance immunosuppressive regime twelve months after renal transplantation in recipients of donor kidney graft on graft function and acute…
The aim of the present study is to compare the following transport characteristics for a modified 3.86% glucose PET preceded by a long (>8 hours) dwell with 3.86% glucose (PET A) and one preceded by a long dwell with 7.5% icodextrin (PET B),…
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To study the effect of acetazolamide on lithium-induced NDI.
Primary objectivesThe primary objective of the study is demonstrate that at least one of the sotrastaurin treatment arms is non-inferior to the active control regimen myfortic + tacrolimus with respect to composite efficacy failure (treated BPAR of…
To find an energy dose for the complete destruction of a renal tumour with bipolar-multipolar RFA.
To develop a workable and effective programma to encourage the self management abilities of people with progressive chronic kidney disease stage 1-4. The evaluation consists of a process- and an effect evaluation.The process evaluation will evaluate…
To investigate if determining dry-weight with the assistance of bioelectrical impedance analysis compared to the current practice will result in a better blood pressure control.
The primary objective of this study is to evaluate the long-term safety and tolerability of the TAK-491CLD FDC in comparison to the OLM/HCTZ FDC in hypertensive subjects with moderate renal impairment.
The objective of this extension study is to find out the potential long-term benefits and safety of tolvaptan. During this study all participants will receive tolvaptan.PRIMARY OBJECTIVE is to demonstrate whether tolvaptan modifies ADPKD progression…
* To evaluate the long-term efficacy of FCM (using targeted ferritin levels to determine dosing) or oral iron to delay and/or reduce erythropoiesis stimulating agent (ESA) use and/or other anaemia management options in NDD-CKD subjects with iron…
We try to find a new standard within the field of ''MicroRNA'' proteins, that swim around in peoples blood and/or urine. MicroRNA's are very small proteins, that switches of genes in the cells, they are able to switch genes…
Primary Objective: to explore the prevalence of urinary concentration defects (NDI) in a Dutch population of lithium treated patients.Secondary Objectives: to determine the relation of the dDAVP test results with complaints (micturition history) and…
Is sympathetic innervation and perfusion disturbed in patients with chronic kidney disease and will is change after HD?
2. OBJECTIVESPrimary Objective: To test the proof of concept whether recombinant HLA molecules (A1, A2, B7, B8) can be used for the monitoring of the indirect allorecognition pathway in renal transplant recipients.Secondary Objective(s): To…
The primary objective is to assess whether renal denervation added to usual care compared to usual care alone reduces BP (office based BP and 24-h ambulatory BP-monitoring) both in subjects with a SBP level above 160 mmHg as well as subjects with a…
Objectives1. To investigate whether the improved hemodynamic stability with Hemocontrol dialysis is based on higher plasma levels of vasopressin or on enhanced activity of the sympathetic nervous system and/or inhibition of nitric oxide production.…