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-Study on the effect of the interaction of short-term combined use of NSAIDS with diuretics and/or RAAS-inhibitor in post-operative elective orthopedic patients

to study the effect of short term combined use of NSAIDS with diuretics/RAAS-inhibitors on the heart and kidneyfunction in orthopedic patients undergowing a knee- or hip-replacement

A Multicenter, Open-Label Study of doxercalciferol capsules for the Treatment of Secondary Hyperparathyroidisms (SHPT) in Stage 3 or Stage 4 Chronic kidney Disease (CKD) Patients

Primary Objective: To evaluate the safety and tolerability of Hectorol Capsules during 52 weeks of treatment in patients with Stage 3 or Stage 4 CKDSecondary Objective: To evaluate the efficacy of Hectorol Capsules during 52 weeks of treatment in…

A Phase I Study of Oral Topotecan in Subjects with Cancer and
Impaired Renal Function

Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…

A twelve-month, multicenter, open-label, randomized study of the safety, tolerability and efficacy of Certican* with Simulect, corticosteroids and two different exposure levels of tacrolimus in de novo renal transplant recipients

With the goal of improving kidney function and without causing an increased number of rejections, is it possible to reduce tacrolimus dosage through the use of the previously-mentioned immunosupressives after month three.

THE EFFECT OF NIACINAMIDE SUPPLEMENTATION ON PHOSPHATE CONCENTATIONS IN DIALYSIS PATIENTS.

The main study parameter is the routine measurement of serum phosphate concentrations after 8 and 12 weeks. Other study parameters are compliance to phosphate binders and supplement-related complaints such as nausea, diarrhoea, flushing and itchness…

Clearance of vasopressin and copeptin during hemodialysis

To study the ratio of copeptin and vasopressin in hemodialysis patients at the start of the dialysis session and if the ratio is affected by the hemodialysis procedure itsself by calculation of the clearance of both molecules with hemodialysis. The…

SoFT - Sevelamer on FGF23 Trial - A clinical trial assessing the quantitative effect of phosphate binding therapy on FGF23.

To demonstrate the feasibility to induce an effective, predictable and sustained decrease in FGF23 level in CKD stage I-IV patients, without inducing hypophosphatemia using a stepped treatment regimen aiming at restricting phosphate uptake.

Dysfunction of bone marrow progenitor cells in chronic kidney disease

1. To quantify and characterize BM progenitor cells in patients with CKD as compared to healthy controls. 2. To explore strategies to improve BM stem and progenitor cell function ex vivo.

Sympathy Redo: redo of renal denervation with a second generation device.

The primary objective is to assess whether RDN by other devices than Medtronic added to usual care compared to usual care alone reduces BP in subjects, classified as non-responders on renal denervation, six months after RDN.

Pharmacodynamic breakpoints for ciprofloxacin efficacy and resistance in critically ill patients treated with continuous venovenous hemodialysis: a prospective case series study.

To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.

Effects of oral iron supplementation on the gut microbiome and plasma uremic toxin levels in patients with chronic kidney disease

This study assesses the effect of oral iron supplementation on gut-derived plasma uremic toxin levels in patients with chronic kidney disease (CKD) and with iron deficiency. The main research questions to be answered are:1. Does oral iron…

Randomized double blind placebo-controlled phase II study on the effects of EA-230 on the innate immune response following on-pump cardiac surgery

To assess safety and tolerability of EA-230 in patients undergoing cardiac surgery with cardiopulmonary bypass.To assess the anti-inflammatory effects of EA-230 in patients with systemic inflammation following cardiac surgery. To assess the effects…

The effectiveness of deep versus moderate neuromuscular blockade
during laparoscopic donor nephrectomy in enhancing postoperative recovery.

To establish the relationship between the use of deep neuromuscular blockade (NMB) during laparoscopic donor nephrectomy (LDN) -with standard pressure pneumoperitoneum- and the early quality of recovery.

SYMPATHY-NTX study Catheter-based Renal Sympathectomy for Hypertension after Kidney Transplantation - a feasibility study.

Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate the Safety and Efficacy of Avacopan (CCX168) in Patients with C3 Glomerulopathy

The primary objective is to evaluate the efficacy of avacopan compared to placebo based on histologic changes in kidney biopsies taken before and during treatment.The secondary objectives of this study include evaluation of:1. The safety of avacopan…

MRI measurement of the effects of moderate versus deep neuromuscular blockade on the abdominal working space during laparoscopic surgery in a prospective cohort study.

The effect of deep muscle relaxation on the abdominal working space during laparosopy, measured by MRI.

A Phase 2, Multicenter, Open-Label, Extension Study to Evaluate the Long-Term Administration of ALN-GO1 in Patients with Primary Hyperoxaluria Type 1.

Primary:* Evaluate the long-term safety of multiple doses of ALN-GO1 in patients with PH1.Secundary:* Evaluate the pharmacodynamic (PD) effect of ALN-GO1 on urinary oxalate excretion* Characterize the effect of ALN-GO1 on markers of renal function.…

The immune-response and safety of COVID-19 vaccination in patients with chronic kidney disease, on dialysis, or living with a kidney transplant

To assess the efficacy and safety of vaccination against COVID-19 in patients with CKD4/5, patients on dialysis, and kidney transplant recipients as compared to controls

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Ranging Study in Healthy Volunteers to Assess Safety, Tolerability, and Evaluate the Pharmacokinetics and Pharmacodynamics of R2R01

In this study we will investigate how safe the new compound R2R01 is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent R2R01 is absorbed and eliminated from the body. In addition…

Rescue Alkaline Phosphatase In Defense against all cause Acute Kidney Injury

To study the potential renoprotective effects of supplementation of alkaline phosphatase in hospitalized patients with AKI