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A 24 month, multi-center, open-label, randomized, controlled study to evaluate the efficacy and safety of concentration controlled everolimus to eliminate or to reduce tacrolimus compared to tacrolimus in de novo liver transplant recipients.

To evaluate the use of concentration-controlled everolimus, with the reduction or the elimination of tacrolimus, to provide superior renal function and to provide non-inferior rates of the composite efficacy endpoint compared to the tacrolimus…

A multi-center, randomized, controlled trial with programmed introduction of Sirolimus-based, Calcineurin inhibitor free immunosuppression in recipients of non-heart-beating donor kidney grafts.

To investigate the safety and efficacy of a programmed introduction of a sirolimus based calcineurin inhibitor free maintenance immunosuppressive regime three months after renal transplantation in recipients of a non-heart-beating donor kidney graft…

A comparison between the effects of icodextrin and glucose 2.27% on plasma volume in peritoneal dialysis patients

The primary hypothesis of the study is that the use of icodextrin leads to a reduction in extracellular volume compared to glucose 2.27%, but that the effects of icodextrin and glucose 2.27% on plasma will not differ.

Protocol CKI-301 KW-3902IV in the treatment of subjects with acute heart failure syndrome
A multicenter, randomized, double-blind, placebo-controlled study of the effects of KW-3902 injectable emulsion on heart failure signs and symptoms and renal function in subjects with acute heart failure syndrome and renal impairment who are hospitalized for volume overload and require intravenous diuretic therapy

To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…

Self-perceived symptoms and care needs of patients with severe to very severe chronic obstructive pulmonary disease, heart failure or renal failure and its consequences for their closest relatives.

1.1 What are the self-perceived symptoms and care needs of patients with moderate to very severe COPD, CHF or CRF and to what extent do they differ from each other?1.2 Do these self-perceived symptoms and care needs relate to patients* daily…

Systemic effects of mild renal insufficiency: the relation between forearm blood flow and ADMA.

The results of this study will give better insights in the role of ADMA in the development of systemic endothelial dysfunction.

A Phase 3, Multi-center, Double-blind, Placebo-controlled, Parallel-arm Trial to Determine Long-term Safety and Efficacy of Oral Tolvaptan Tablet Regimens in Adult Subjects with Autosomal Dominant Polycystic Kidney Disease

Primary objective:* Evaluate long-term effect of tolvaptan in ADPKD through rate of renal volume change(%) for tolvaptan-treated compared to placebo-treated subjects.Secondary objectives:* Evaluate long-term efficacy of tolvaptan in ADPKD through a…

The effects of conjugated linoleic acid on the liver enzyme activity

To show whether an intake of 20g CLA per day has negative effects on liver and kidney function in healthy human volunteers.

Danaparoid dosing during continuous venovenous hemofiltration - a randomized controlled pilot study investigating two danaparoid dosing schemes with a standard heparin dosing scheme

The aims of the current study are1. to investigate the efficacy and safety of a continuous infusion of 'low dose' danaparoid in patients with acute renal failure needing CRRT2. to investigate whether repeated measurements of anti-Xa levels…

A prospective, randomized, open, multicenter study to evaluate the efficacy and tolerability of induction therapy with a single high-dose anti-T-lymphocyte globulin (ATG-Fresenius) in renal transplant patients with a kidney from a non-heart-beating donor and tacrolimus, mycophenolate mofetil, and steroids as basic immunosuppression.

With an one-off infusion of anti-thymocyte globulin (ATG) during the operation the T-cell function is decreased. With this action we try to achieve that DGF does not occur or that the length of the DGF is as short as possible and less frequent…

A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multi-center, International Study to Evaluate the Efficacy and Safety of Oxabact(TM) to Reduce Urinary Oxalate in Subjects with Primary Hyperoxaluria.

Primary Objective:To evaluate the efficacy of Oxabact TM to reduce urinary oxalate levels from Baseline to Week 24 in subjects with Primary Hyperoxaluria (PH).Secondary Objectives:To evaluate:* Percentage of subjects who have 20% or greater…

Comparison of the action of amiloride and thiazide in the reduction of lithium-NDI in patients with affective disorders

To compare the effect of amiloride on lithium-induced Nephrogenic Diabetes Insipidus with the effect of hydrochlorothiazide, measured as urine volume and maximal urine osmolality.

Neutrophil Gelatinase-Associated Lipocalin as an early detector of ischemic tubular injury in patients admitted to a general Intensive Care Unit.

Objective: Evaluation of the supposed correlation between increased serum and urine NGAL levels (> 350 ng/ml) and significant increases in serum creatinine levels in adult ICU patients compared to preclinical levels

Circadian rhythm of erythropoietin and melatonin in patients with various degrees of renal insufficiency, Part one

Primary objective: Is there a similar circadian rhythm of epo and melatonin in patients with the same degrees of renal insufficiency?Primary Objective: Is there a similar circadian rhythm of epo and melatonin in patients with various degree of renal…

Evaluation of the clinical value of contrast enhanced ultrasound in the diagnostic and follow-up of renal cell cancer

We would like to investigate the role of CE-US with Sonovue (Bracco) in patients with RCC. Our primary objective is to establish the diagnostic accuracy of CE-US in renal masses suspicious for RCC.Our secondary objective is to establish the pattern…

A multicenter, randomized, double-blind, placebo-controlled study of the effects of KW-3902 Injectable Emulsion on heart failure signs and symptoms, diuresis, renal function, and clinical outcomes in subjects hospitalized with worsening renal function and heart failure requiring intravenous therapy.

The objectives of this study are to evaluate the effect of KW-3902IV, in addition to standard therapy, on the proportion of worsening heart failure and worsening renal function after initiation of therapy through Day 7 or discharge, whichever occurs…

A Multicenter, Open-Label Study of doxercalciferol capsules for the Treatment of Secondary Hyperparathyroidisms (SHPT) in Stage 3 or Stage 4 Chronic kidney Disease (CKD) Patients

Primary Objective: To evaluate the safety and tolerability of Hectorol Capsules during 52 weeks of treatment in patients with Stage 3 or Stage 4 CKDSecondary Objective: To evaluate the efficacy of Hectorol Capsules during 52 weeks of treatment in…

Renal involvement in chronic progressive external ophthalmoplegia

The goal of this study is to answer the following questions:1. Is the chance of detecting mtDNA mutations in blood or urine sediment as high as in a (much more invasive) skeletal muscle biopsy sample?2. What is the prevalence of renal failure in…

Towards a further extension of the potential donor pool for highly sensitized patients.

The aim of this project is to enhance transplantation prospects of highly sensitized patients who are waiting for a long time for a suitable kidney graft. Despite their inclusion in the Acceptable Mismatch (AM) program (initiated in The Netherlands…

A Phase I Study of Oral Topotecan in Subjects with Cancer and
Impaired Renal Function

Primary• To determine the safety profile of oral topotecan in subjects with cancer andmildly moderately or severely impaired renal function (Groups C, D and E) compared to subjects with cancerwhose renal function is normal and who have received…