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Urological complications after live donor kidney transplantation: intravesical or extravesical ureterovesical anastomosis?

Main objective: Does the use of the extravesical ureterovesicostomy reduce the incidence of PCN placement, and urological complications?Secondary objective: Does the use of the extravesical ureterovesicostomy reduces the rate of re-operations and re…

A prospective, open, randomized, single center study comparing the effects of duo therapy with Everolimus and steroids versus triple treatment of low dose calcineurin inhibitor, low-dose MMF and steroids at least one year after renal transplantation.
Effects on renal function, tolerability, chronic allograft damage, cardiovascular parameters and malignancies.

Objective: To investigate the safety and efficacy of a therapy consisting Everolimus and corticosteroids maintenance immunosuppressive regime twelve months after renal transplantation in recipients of donor kidney graft on graft function and acute…

The effect of acetazolamide on lithium-induced nephrogenic diabetes insipidus in patients with an affective disorder: a pilot study

To study the effect of acetazolamide on lithium-induced NDI.

A partially blinded, prospective, randomized multicenter study evaluating efficacy, safety and tolerability of oral sotrastaurin plus standard or reduced exposure tacrolimus vs. myfortic plus tacrolimus in de novo renal transplant recipients (CAEB071A2214)

Primary objectivesThe primary objective of the study is demonstrate that at least one of the sotrastaurin treatment arms is non-inferior to the active control regimen myfortic + tacrolimus with respect to composite efficacy failure (treated BPAR of…

Bipolar-Multipolar Radiofrequency Ablation of Small Renal Masses (<=4cm)

To find an energy dose for the complete destruction of a renal tumour with bipolar-multipolar RFA.

Improvement of dry-weight in dialysis patients using bioelectrical impedance analysis

To investigate if determining dry-weight with the assistance of bioelectrical impedance analysis compared to the current practice will result in a better blood pressure control.

A Randomized, Open-Label, Phase 3 Study to Compare Long-Term Safety and Tolerability of
the TAK-491 and Chlorthalidone Fixed-Dose Combination Versus Olmesartan Medoxomil and
Hydrochlorothiazide Fixed-Dose Combination in Hypertensive Subjects With Moderate Renal
Impairment

The primary objective of this study is to evaluate the long-term safety and tolerability of the TAK-491CLD FDC in comparison to the OLM/HCTZ FDC in hypertensive subjects with moderate renal impairment.

Multi-center, Open-label, Extension Study to Evaluate the Long-term Efficacy and Safety of Oral Tolvaptan Tablet Regimens in Subjects with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

The objective of this extension study is to find out the potential long-term benefits and safety of tolvaptan. During this study all participants will receive tolvaptan.PRIMARY OBJECTIVE is to demonstrate whether tolvaptan modifies ADPKD progression…

An Open-label, Multicentre, Randomised, 3-arm Study to Investigate the Comparative Efficacy and Safety of Intravenous Ferric Carboxymaltose (Ferinject® High- and Low-dosage Regimens) versus Oral Iron for the Treatment of Iron Deficiency Anaemia in Subjects with Non-dialysis-dependent Chronic Kidney Disease

* To evaluate the long-term efficacy of FCM (using targeted ferritin levels to determine dosing) or oral iron to delay and/or reduce erythropoiesis stimulating agent (ESA) use and/or other anaemia management options in NDD-CKD subjects with iron…

SYMPATHY: Renal sympathetic denervation as a new treatment for therapy resistant hypertension: from rescue to resolve.

The primary objective is to assess whether renal denervation added to usual care compared to usual care alone reduces BP (office based BP and 24-h ambulatory BP-monitoring) both in subjects with a SBP level above 160 mmHg as well as subjects with a…

Is the lower incidence of intradialytic hypotension during Hemocontrol dialysis in comparison with standard hemodialysis attributable to enhanced to higher plasma vasopressin levels or to enhanced sympathetic activity and/or to less nitric oxide production?

Objectives1. To investigate whether the improved hemodynamic stability with Hemocontrol dialysis is based on higher plasma levels of vasopressin or on enhanced activity of the sympathetic nervous system and/or inhibition of nitric oxide production.…

A STUDY OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF LY3045697 AFTER SINGLE ORAL DOSING IN HEALTHY SUBJECTS

Primary : To evaluate the safety and tolerability of single oral doses of LY3045697 administered to healthy subjects Secondary : To investigate the pharmacokinetics of single oral doses of LY3045697 administered to healthy subjects Exploratory : To…

A 24 month, multi-center, open-label, randomized, controlled study to evaluate the efficacy and safety of concentration controlled everolimus to eliminate or to reduce tacrolimus compared to tacrolimus in de novo liver transplant recipients.

To evaluate the use of concentration-controlled everolimus, with the reduction or the elimination of tacrolimus, to provide superior renal function and to provide non-inferior rates of the composite efficacy endpoint compared to the tacrolimus…

A STUDY OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF LY3045697 AFTER MULTIPLE ORAL DOSING IN HEALTHY SUBJECTS

Primary: To evaluate the safety and tolerability of LY3045697 after multiple oral dosing in healthy subjectsSecondary: To investigate the pharmacokinetics of LY3045697 after multiple oral dosing in healthy subjects

Catheterbased REnal SympatheCtomy for hypErteNsion after kidneyTranplantation

To test the efficacy of renal sympathetic denervation therapy with a special focus on preservation of renal allograft function.

Effects of Self-monitoring on Outcome of Chronic Kidney Disease

The overall aim of the project is to improve health outcomes and autonomy of CKD patients by testing a self-management care model regarding hypertension control. Furthermore, this study will investigate the impeding and facilitating factors for…

AN OPEN LABEL STUDY TO EVALUATE THE PHARMACOKINETICS OF ASP7035 AFTER A SINGLE ORAL DOSE OF 14C-LABELED ASP7035 IN HEALTHY MALE SUBJECTS

Primary:- to evaluate the pharmacokinetics, in particular the routes and extent of metabolism and excretion, of the study medication after a single oral dose of 1 mg 14C-labeled study medicationSecondary: -to identify the metabolic profile of the…

A multi-center, parallel-group, comparative trial evaluating the efficacy, pharmacokinetics and safety of 4.0 mg.kg-1 sugammadex administered at 1-2 PTC in subjects with normal or severely impaired renal function

Objective is to show equivalence with respect to the efficacy of sugammadex in subjects with normal or severely impaired renal function, to evaluate the safety of sugammadex in these subject groups and to compare the pharmacokinetic profiles.

Study of the Safety, Tolerability and Pharmacokinetics of LY2623091 after Single Oral Dosing in Healthy Subjects

Primary objective:- to investigate the safety and tolerability after a single oral dose in healthy men and women of non-childbearing potential. Secondary objective:- to investigate the pharmacokinetic of a single oral dose in healthy men and women…

A 24-month, multi-center, open-label, randomized, controlled trial to investigate efficacy, safety and evolution of cardiovascular parameters in de novo renal transplant recipients after early calcineurin inhibitor to everolimus conversion (CRAD001A2429, ELEVATE study)

Primary objective: To demonstrate superior renal allograft function in de novo renal transplant recipients after early CNI to everolimus conversion assessed by Glomerular Filtration Rate (eGFR) estimated by the Modification of Diet in Renal Disease…