22 results
Objective: To determine the incidence of asymptomatic oral and corneal HSV-1 shedding.
The overall objectives of the study are to evaluate the safety and efficacy (anatomical and functional visual outcomes) of two doses of GT005 in genetically defined subjects with GA due to AMD.
To gain insight into the incidence of retinopathy and optic neuropathy in relation to the radiation dose in order to develop a normal tissue complication probability (NTCP) model for the eye and the optic tract.
Development of a laboratory assay
The aim of this study was to test these biomarkers of NO in glaucoma patients both with and without tinnitus. The objective was also to replicate findings from a previous study performed in Amsterdam, a collaboration between our research group and…
The objective of this project is to evaluate whether the effectiveness of customized cross-linking (cCXL) is non-inferior to the standard cross-linking protocol (sCXL).
To determine whether functional and/or structural retinal biomarkers or circulating biomarkers are able to differentiate people with mild cognitive impairment (MCI) within the type 2 diabetes (T2D) population (this we will be able to do in the…
To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.
The purpose of this study is to evaluate the efficacy and safety of brolucizumab used in a Treat- to-Control (TtC) regimen with maximum treatment intervals up to 20 weeks for the treatment of patients with neovascular age-related macular…
The primary goal of this study is to identify the presence and possible pathogenic role of auto-antibodies in scleritis patients. Secondary goals are to evaluate the presence and role of matrix metalloproteinases (MMPs) in scleritis and its…
To determine whether functional and/or structural retinal biomarkers or circulating biomarkers can be used to determine the speed of cognitive decline in people with T2D and MCI and those at higher risk of developing dementia.
The purpose of this study is to evaluate the long-term safety of the PRESERFLO® MicroShunt in subjects with Primary Open-Angle Glaucoma who have completed participation in the INN-005 clinical study, conducted under IDE G130028, by collecting safety…
The objective of this study is to evaluate the effectiveness of different treatments to prevent CME after cataract surgery, using either topical drugs (control group) or intra-/periocular injections (intervention groups).
Part 1 SAD:Primary objective: To evaluate the safety and tolerability of single ascending doses of ANXV in healthy subjects.Secondary objective: To determine the PK profile of single ascending doses of ANXV in healthy subjects.Part 2 MAD:Primary…
To investigate visual function recovery after surgery for foveal splitting RRD.
Primary Objective: To determine when straylight stabilizes in eyes after cataract surgery, determine the amount of straylight in eyes implanted with a Clareon monofocal IOL and a Vivinex XY1 monofocal IOL, and compare these straylight values to…
1. Optimize the EMC-test*s potential to predict the SAP-parameter Mean Deviation (MD), based on simulated visual field defects in healthy observers.2. Refine the EMC-test*s potential to predict the SAP-parameter MD in patients.
1. To report the natural history of retinal degeneration in patients with biallelic mutations in the EYS gene.2. To identify sensitive structural and functional outcome measures to use for future multicenter clinical trials in EYS-related retinal…
To demonstrate that DMEK is superior to DSAEK with respect to visual acuity and quality of vision.
To correlate structural modifications with visual function in patients after macula-on retinal detachment.