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From shape to wavefront: retrieving optical aberrations from corneal anatomy

To determine the aberration pattern of the cornea from its shape.

Pathogenesis, diagnostics and complications of uveitis in childhood.

First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…

The Aqueous Humor Ferritin Level in Hereditary Hyperferritinaemia-Cataract Syndrome

To determine the normal ferritin level in the anterior chamber, and to compare this with the ferritin level in HHCS patients.

Causes, risk factors, complications and treatment of uveitis in childhood

First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…

Prospective, open label, single arm, First in Human (FIH) clinical study to assess Safety and efficacy of the CorNeat Keratoprosthesis for the treatment of corneal blindness

The objective of this clinical study is to prove the safety of the CorNeat KPro.

Effectiveness of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus

The objective of this project is to evaluate whether the effectiveness of customized cross-linking (cCXL) is non-inferior to the standard cross-linking protocol (sCXL).

AN OPEN-LABEL MULTICENTER PHASE 2 CLINICAL SAFETY INVESTIGATION OF THE ENDOART® IMPLANTATION IN SUBJECTS WITH CHRONIC CORNEAL EDEMA

To evaluate the safety of EndoArt® in subjects with chronic corneal edema.

Bowman layer transplantation for treatment of corneal contour deformations

To determine whether corneal stabilization can be achieved using a BL onlay and minimize the risk of complications which occur during more invasive techniques. This would also be a technically less demanding surgical procedure.

A Single Arm, Open Label, Multicenter Clinical Investigation to Evaluate the Clinical Safety and Performance of the CorNeat Keratoprosthesis, for Treatment of Corneal Blindness

This clinical trial will assess the clinical safety and performance of the CorNeat KPro.

Whole Exome & Whole Genome Sequencing Analysis to Explore Familial Keratoconus

To identify genetic variants for the development and progression of keratoconus using Whole Exome Sequencing and Whole Genome Sequencing approaches on keratoconus families with index patients originating from the Rotterdam Eye Hospital and Erasmus…

Smartphone enabled device for remote ophthalmological evaluation

Study part 1A) To determine specificity and sensitivity of diagnosis of anterior ocular pathology with the smartphone enabled device, as compared to in-clinic slit-lamp and tonometry examination (gold standard).B) To determine ease of use of the…

Molecular background of endothelial cell loss in patients with phakic intraocular lenses (MoBack-ECL): a tear and aqueous humour analysis study

The primary objective of the study is to explore the role of inflammation in the anterior chamber on endothelial cell loss in patients implanted with iris-fixated pIOLs. The secondary objective is to identify whether there is a correlation between…