557 results
(1) To investigate the relationship between estradiol level and ADHD and mood symptoms within the menstrual cycle in women with ADHD. (2) To investigate if this relationship is comparable between women with and without ADHD.
We will study the cerebral glucose metabolism before, during and after surgery by sampling the cerebrospinal fluid (CSF) via the spinal catheter in patients undergoing thoracic surgery. Changes in cerebral glucose metabolism and activation of the…
The objectives of this study are threefold. First, we aim to understand the underlying neural mechanisms of suicidality. Therefore, we will investigate brain activation during resting state and three psychological processes that have been suggested…
We hypothesize that improving sleep will improve glycaemic control in people with T2DM and insomnia. To test this hypothesis, we established the following objectives: 1) investigate if improving sleep by internet-based cognitive behavioural therapy…
The primary objective is twofold. First, we aim to investigate how the brain responds to acute stress and, second, which factors explain variability underlying brain activity following acute stress. The study population consists of extremely preterm…
The main objective of this study is to identify prognostic, stratification, and/or outcome biomarkers for ASD. Prognostic marker refers to any objectively measurable test that helps to predict a child's likely developmental course; whether his…
Objectives: 1) Assess neural and cognitive biomarkers (through eye-tracking, EEG/ERP and cognitive measures) in a community sample of infants at heightened non-familial risk for ASD and in age and gender matched low-risk controls. The HR group is…
The primary objective of the MANTA-study is to investigate MEG-based network topology and 'activity dependent degeneration' as mechanisms in the stereotypical spread of tau pathology (18F-AV1451 retention) in preclinical and clinical…
To provide an answer to the following questions: 1. In patients with AD, does treatment with a ChEI improve cerebral hemodynamics? 2. Is there less progression of cerebrovascular lesions on follow-up of AD patients receiving ChEI*s? 3. Does this…
Main goal is to gain more insight in the role of dopaminergic neurotransmission in rewards, motivation and the attribution of salience in the etiology of psychosis. Primary question is whether a change in blood oxygation level dependent (BOLD) fMRI…
A longitudinal cohort of 550-600 children will be set up (10-25 years old, 450 children with and 100-150 children without a parent with mood disorders) on basis of already identified participants (parents) that are part of the NESDA, BiG, OPPER,…
To study the differences in MI between short-term ill adolescents with AN (< illness duration 1 year) and patients who started their illness in adolescence and have been ill for at least 5 years consecutively and with healthy controls. A…
1) To compare between treatment responders, treatment non-responders, and healthy controls: sDSC and GABA in the ACC;2) To assess, in psychotic patients and healthy controls, whether AEA and 2-AG plasma levels are associated with sDSC, and…
To provide an extensive clinical and psychosocial characterization of IBS patients with and without psychological and/or physical comorbidities, as well as of disease-controls without IBS, but with psychological and/or physical disease, and a…
Primary:- Investigate the feasibility of examining fetal and neonatal brain developmental trajectories in the fetus and neonate with at least one parent with SMI in the mood-psychosis spectrum (vs. parents without SMI) using MRI.- Acquire…
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.
To investigate the role of the dopaminergic system in reward discounting and reward anticipation in ADHD and comorbid disorders. The study investigates the following question: Do patients with ADHD without comorbidity differ from those with ADHD and…
1) Identify potential mechanism(s) underlying the impact of an FFD on ADHD symptoms;2) Identify biomarkers that predict the response to the FFD.
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…