557 results
The study has 3 substudies with each their separate goals:Neuroimaging part:1. To determine the effects of DBS on D2 receptor binding. 2. To determine alterations in cerebral perfusion associated with deep brain stimulation (DBS).Neuropsychological…
We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…
1. To make a phenomenological profile of BIID individuals using a standardized questionnaire.2. To perform whole exome analyses in four phenomenological identical BIID individuals.3. To perform molecular analyses in a series of other BIID…
The aims of the study are (1) to establish the feasibility, safety, and potential efficacy of NcAcc DBS in patients with a chronic, treatment refractory heroin and/or cocaine addiction; (2) to explore functional effects of NcAcc DBS in terms of…
To examine the role of fear and disgust in acute and chronic PTSD symptoms.In study 1 we will investigate (1) whether the US-representation of burglary involves danger and disgust-related elements that contribute independently to PTSD symptoms and (…
The aim of this study is to investigate the temporal dynamics between depressive symptoms and physical activity in post-MI patients, in order to prevent the deleterious effects of depression on heart disease prognosis and improve patient counselling…
The goal of the present study is to describe this unique sample on the basis of dossier analysis at the time of referral and reassess all individuals for follow up. VERPLAATST: The main objective of this study is to assess long-term outcome of…
To get insight into the prevalence of a whole range of psychiatric symptoms of parents of children who have been admitted to an outpatient clinic for child and adolescent psychiatry for various psychiatric symptoms and the parent-offspring…
With this research-protocol we aim to investigate six important issues regarding recurrences of MDD-episodes:1. The differences between healthy controls and patients with recurrent MDD-episodes with respect to structural (sMRI) and functional (fMRI…
Does simulated pareses show different cerebral activation patterns compared to conversion pareses within patients?
The current protocol aims to test the effects of intervals between subsequent startle measurements on the sensitivity of FPS to alcohol.
Goal of this study is to research family factors in case of adolescents with MUPS (N=64) and in case of adolescents with medically unexplained physical complaints (N=64). The following family factors are studied: family functioning (for example,…
To investigate if persistent pro-inflammatory changes in monocytes and T-cells are associated with exposure to migration early in life, and if these changes mediate the relationship between migration and schizophrenia.
1. Advance knowledge of the cognitive and neural mechanisms underlying emotional dysregulation in borderline personality disorder. 2. Advance knowledge on the cognitive and neural mechanisms of dialectical behaviour therapy in borderline personality…
We aim to investigate amygdalar functional connectivity in young people with autism using non-invasive fMRI measures. Specifically, we aim to investigate the functional connectivity of the amygdalar nuclei to the rest of the brain.
* To examine the effects and interactions of individual and environmental factors on the onset and course of mental health problems in adolescents and young adults.* To examine the effects and interactions of individual and environmental factors on…
Aim of this proposal is to unravel the changes in functional neural networks in healthy human brain and in schizophrenia at 7T. We hypothesize a difference in brain changes between healthy individuals and patients with schizophrenia and abnormal…
In the current study we will prospectively investigate whether pre-trauma differences in expectancy learning and evaluative conditioning, and posttrauma differences in inhibitory learning predict PTSD symptoms at follow-up. A larger US-expectancy…
We intend to study the role of fronto-striatal circuitry and cognitive control in the inflexible behaviour that is a defining feature of autism.
The objective of this study is to investigate the effects of replicated and theoretically interesting autism risk genes on brain anatomy in ASD. We will use psychiatric genetics and gene expression patterns to predict neuroimaging findings in ASD.