557 results
The primary objective of the SCIENCe project is to establish a prospective cohort of patients with subjective complaints, to study the earliest brain changes ultimately leading to cognitive decline and dementia due to AD. Specific research questions…
This cohort study aims to explain why some children develop well and others fail to thrive in society. To this purpose, we examine how neurocognitive development mediates the association between developmental changes in biological, child-related and…
The overall aim of this study is to investigate the pathophysiology of PPMD, and identify predictors of longitudinal outcome.Primary Objective: The primary objective is to investigate the underlying neurobiology of first-onset PPMD using…
The current pilot study aims to investigate whether diversity and composition of the intestinal microbiota are different in patients with enduring anorexia nervosa compared to matched controls. Furthermore, this study aims to explore whether…
The current study aims to investigate whether vitamin and mineral status is associated with executive functioning in patients with an eating disorder. Key objectives: 1.To investigate the micronutrient status in patients with an eating disorder…
Primary Objective:1)To examine whether exposure to bullying victimization in adolescence is associated with the CTRA transcriptome profile(increased pro-inflammatory gene expression and decreased antiviral and antibody-related gene expression) in…
to assess general sexual functioning, genital sexual responsiveness, subjective sexual responsiveness and affect in women with PCOS , and to make a comparison of these results with the results of an age matched healthy control group of women.…
We aim to study the association between (clusters of) genes or genetic pathways and phenotype in a population of people with a rare genetic variant and a (suspected) ASD. We will do this by 1) describing the individual participant, 2) comparing…
To determine if dopaminergic dysfunction and neuroinflammation is increased in patients with TRD compared to patients who respond to antidepressant medication
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
Our primary objective is to investigate the relation between atypical IMP and SINDA scores in infancy and symptoms of DCD at 4-5 years of age measured with the Movement Assessment Battery for Children - 2nd edition. The relation will also be…
The main objective of this study is to identify similarities and/or differences in social cognition between males and females with ASD at the behavioral, neuropsychological, and neurophysiological level during adolescence.
To define a link between excitatory/inhibitory (glutamate/GABA) neurotransmission and neural functioning across different brain regions (regional specificity) and to establish the relation between this link and ASD symptomatology (tapping into…
The main aim of this proposal is to characterize the neurobiological basis of sensory processing deficits in ASD. The first key objective is to exploit our Netherlands Autism Register to pre-select extreme cases of high- and low sensory sensitivity…
The aim of the current study is to identify how increased genetic risk for developing a psychotic disorder affects brain development by studying neurobiological and neuropsychological, clinical an environmental markers in first and second degree…
Primary Objective: To identify immuno-endocrine and neuro-imaging parameters differentiating between different mood states (manic, depressive, and euthymic). Secondary Objectives: 1. To identify the influence of these parameters on the onset and…
The main aim of the current study is to identify a set of neurobiological markers that contribute to the prediction, distinction and prevention of reactive and proactive aggressive behavior. The study has two primary objectives: 1) to study whether…
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
To investigate plasticity in the visual cortex in NF1 patients, we will compare the VEPs evoked by checkerboard reversals at baseline and after a modulation block at T1, T2 and T3 of NF1 patients with those of controls.
Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…