60 results
Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…
The main objective of the current project is to characterize hippocampal neural (dys)function in the process pattern separation by comparing subjects along their performance on a behavioural pattern separation task.
In this proof-of-concept study, we aim to characterize healthy individuals with regard to their individually predominant neural mechanism. Thereby, we aim to divide a sample of healthy individuals into three clusters based on their individual…
Our primary objectives are to study in patients with OCD 1.) Whether stress facilitates a shift from goal-directed to habitual behaviour (both appetitive and avoidant); 2.) Whether stress facilitates compulsive behavior through an enhancement of…
Primary Objective: Using fMRI to assess differences in brain activation during: (a) up- and down-regulation of emotional reaction to negative and positive pictures vs neutral pictures; and (b) working memory at low and high load with emotional…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…
Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…
If normal doubt occurs, will OCD patients differ from non-OCD anxiety patients and healthy controls in how much uncertainty they will experience and will OCD patients respond to this with more perseveration (chekcing behavior) than non-OCD anxiety…
Primary objective 1: Does repeated relevant checking in general lead to automatization in OCD patients? Primary objective 2: If automatization as a result of repeated relevant checking occurs, do OCD patients differ from other anxiety disorder…
The overall aim of this study is to investigate interoceptive conditioning of fear and it*s generalization in both panic/anxiety patients and healthy control subjects. Therefore we have three specific objectives. The first objective is to replicate…
The objective for this study is to examine alpha suppression in PTSD and evaluate it as a predictor of treatment outcome. We will first examine if there are differences in alpha suppression PTSD patients (prior to treatment) and the typical…
RESEARCH QUESTIONS* Is the currently used RNAF protocol for the acute medical care on the Battlefield sufficient.* What recommendation can be made to enhance this protocol, with emphasis on the transfer of information from battle field to second…
The first objective is to assess the effect of age and anxiety disorder on use and effectiveness of emotion regulation strategies in circumscribed vs. complex daily life situations. The second objective is to assess the effect of treatment of…
1. Examine the physiological, endocrinological and neural differences between children with PTSD and without PTSD2. Examine if neurobiological treatment effects of TF-CBT and EMDR differ and if so how3. Examine if neurobiological treatment effects…
To examine the role of fear and disgust in acute and chronic PTSD symptoms.In study 1 we will investigate (1) whether the US-representation of burglary involves danger and disgust-related elements that contribute independently to PTSD symptoms and (…
The goal of the present study is to describe this unique sample on the basis of dossier analysis at the time of referral and reassess all individuals for follow up. VERPLAATST: The main objective of this study is to assess long-term outcome of…
The current protocol aims to test the effects of intervals between subsequent startle measurements on the sensitivity of FPS to alcohol.
In the current study we will prospectively investigate whether pre-trauma differences in expectancy learning and evaluative conditioning, and posttrauma differences in inhibitory learning predict PTSD symptoms at follow-up. A larger US-expectancy…
The objective of the proposed research is to gain insight into the circumstances under which anxiety and avoidance behaviour can develop. More precisely, the goal of the current trial is to determine whether a genetic basis exists for the individual…
1) What is the long-term course of tics and comorbid OCD, ADHD and Quality of life in patients with GTS? 2) What are determinants of favourable versus unfavourable course?