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Towards individual medicine in ADHD: A pilot study on using individual differences in neural reward sensitivity to predict the efficacy of a behavioral intervention in ADHD (The SCORE! study).

To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…

Longitudinal Preterm Outcome Project, growth, health and development during adolescence

First, to compare MLP children with FT and with EP peers regarding intelligence at age 14 to 15 years. Second, to compare MLP children with FT and with EP peers regarding health, health-related behaviors, growth measures, blood pressure, pubertal…

Blood-Brain Barrier function: The key to successful cognitive aging?

The present study will investigate the association between Blood-Brain Barrier leakage and cognitive aging.Primary research question:1. a. Is stronger BBB leakage associated with greater decline in episodic memory?b. Post-hoc explorative analyses…

The psychometric properties of the Zuidwester Balans Schaal (ZBS).

The objective is to research the psychometric properties (feasability, reliability and validity) of the Zuidwester Balans Schaal.

Cortical inhibition and cortical plasticity in individuals with Neurofibromatosis type 1 using transcranial magnetic stimulation

The primary objectives is to determine the difference in cortical inhibition and cortical plasticity between NF1 patients and unaffected controls.

A Two Arm Randomized Clinical Trial comparing the effects of an Elimination Diet and a Healthy Diet in Children with ADHD (TRACE Study). Effects on the Brain * an exploratory investigation

Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…

A single-center, non-randomized, open-label, parallel group, two-treatment study investigating the absolute oral bioavailability of balovaptan after single and multiple daily oral doses of balovaptan in healthy volunteers*

The purpose of the study is to investigate how quickly and to what extent balovaptan is absorbed and eliminated from the body when it is administered to healthy volunteers. The pharmacokinetics of balovaptan given by mouth (oral) will be compared…