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Dopaminergic mechanisms of gating working memory, learning, and motivation: A pharmaco-fMRI study

The primary objective of this study is to unravel the effects of dopamine D2 receptor stimulation on gating of working memory, reinforcement learning, and reward-based motivation, and their associated physiological changes (measured with fMRI and…

The difference in pharmacodynamic and pharmacokinetic profiles between Tentin and magistral dexamphetamine in adults with attention deficit hyperactivity disorder, a double blinded randomised crossover-controlled trial.

The primary objective is to compare the pharmacological profile of the magistral form of dexamphetamine sulphate to the pharmacological profile of the brand-name form of dexamphetamine (Tentin©) in adult patients diagnosed with attention deficit…

Do effects of methylphenidate decline after long-term use? A double-blind, placebo-controlled cross-over study of effects of methylphenidate on cognitive functioning and real world behavior in treatment naïve children compared to effects after 9 months of treatment in clinical practice

The main objective of this study is to compare the acute effects of methylphenidate on behavioral and cognitive functioning in 6 to 12 year old treatment naïve children compared to the effects after nine months of treatment with methylphenidate in…

Do patients benefit from an Attentional Avoidance Training during an inpatient alcohol detoxification?

The aims of the present study are: (1) to assess for the first time in the Netherlands the effectiveness of an adjunctive Alcohol Avoidance Training (AAT) during inpatient alcohol detoxification to improve treatment outcomes. (2) To investigate for…

Examining the pharmacokinetic and pharmacodynamic profile of biperiden

We will examine the cognitive performance of healthy young participants at different time points after a single administration of biperiden. The behavioural outcomes and electrophysiological correlates will be linked with the serum levels of…

The feasibility of working memory training in COPD patients and the efficacy on cognitive performance, self-control, and stress response

Investigating the efficacy and feasibility of working memory training in COPD patients on cognitive performance, cognitive stress susceptibility and perception, self-control / impulse control, and adherence to physical activity and dietary…

The effect of Lamotrigine on cognitive deficits associated with Neurofibromatosis type 1: a phase II randomized controlled multi-centre trial (NF1-EXCEL)

The objective of this proposal is to determine the effect of Lamotrigine on cognitive functioning and neurophysiology in adolescents with NF1.

Clinical pilotstudy in the effect and feasibility of online cognitive training on cognitive functions in patients with Parkinson's disease, Multiple Sclerosis and depressive patients treated with electroconvulsive therapy

The objective of this pilotstudy is primarily to assess a cost-efficient, easy accessible training of cognitive functions on its feasibility and initial effect in patients with cognitive dysfunction in PD, MS of patients treated with ECT. Using this…

Efficacy of the BrainGame Brian training in children born very preterm with attention problems.

Primary objective:investigating whether in a large, representative sample of premature born children (gestational age * 30 weeks and/or birth weight * 1000 gram) with attentional problems in the age of 8 - 12, executing the BrainGame Brian training…

The role of glutamate in cognition in adults with chromosome 22q11 deletion syndrome

The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…