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Towards individual medicine in ADHD: A pilot study on using individual differences in neural reward sensitivity to predict the efficacy of a behavioral intervention in ADHD (The SCORE! study).

To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…

Longitudinal Preterm Outcome Project, growth, health and development during adolescence

First, to compare MLP children with FT and with EP peers regarding intelligence at age 14 to 15 years. Second, to compare MLP children with FT and with EP peers regarding health, health-related behaviors, growth measures, blood pressure, pubertal…

The role of glutamate in cognition in adults with chromosome 22q11 deletion syndrome

The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…

Cortical inhibition and cortical plasticity in individuals with Neurofibromatosis type 1 using transcranial magnetic stimulation

The primary objectives is to determine the difference in cortical inhibition and cortical plasticity between NF1 patients and unaffected controls.

A Two Arm Randomized Clinical Trial comparing the effects of an Elimination Diet and a Healthy Diet in Children with ADHD (TRACE Study). Effects on the Brain * an exploratory investigation

Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…