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MRI determinants of long-term trajectories of ADHD

To identify brain determinants (moderators) and mechanisms (mediators) of ADHD persistence into adulthood by studying fine-grained neuroanatomy and connectivity in a longitudinal study of genetically stratified patients across the full spectrum of…

A single-center, randomized, open-label, four-period, four-treatment, cross-over study to investigate the comparative bioavailability of dispersible tablet and capsule formulations of RO5285119 in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent RO5285119 is absorbed from the gut and then eliminated from the body (this is called pharmacokinetics).It will also be investigated to what extent RO5285119 is tolerated.

Hospital at Home care for elderly patients with cognitive impairment presenting on the emergency department with acute somatic illness and an indication for hospital admission: a randomized feasibility trial

The aim of the study is to assess the feasibility of conducting a definitive trial in terms of recruitment, use and acceptability of H@H, quality of care and the advantages and disadvantages of H@H in comparison to usual hospital care.

COGTIPS (COGnitive Training In Parkinson Study): The effect of online cognitive training on cognitive function and brain networks in Parkinson's disease

The study objective is primarily to measure the effect of an online cognitive training in patients with mild cognitive complaints in PD. An online training, specifically altered for PD patients (BrainGymmer) will be compared with an active online…

Biomarkers for outcome at school age in preterm born children

The objective of the study is to identify biomarkers that associate to brain (physiological) status or mental (functional) health status and their interaction. More specific, our first aim is to determine the association between neuroinflammatory…

The feasibility of working memory training in COPD patients and the efficacy on cognitive performance, self-control, and stress response

Investigating the efficacy and feasibility of working memory training in COPD patients on cognitive performance, cognitive stress susceptibility and perception, self-control / impulse control, and adherence to physical activity and dietary…

Longitudinal Preterm Outcome Project, growth, health and development during adolescence

First, to compare MLP children with FT and with EP peers regarding intelligence at age 14 to 15 years. Second, to compare MLP children with FT and with EP peers regarding health, health-related behaviors, growth measures, blood pressure, pubertal…

Blood-Brain Barrier function: The key to successful cognitive aging?

The present study will investigate the association between Blood-Brain Barrier leakage and cognitive aging.Primary research question:1. a. Is stronger BBB leakage associated with greater decline in episodic memory?b. Post-hoc explorative analyses…

Cortical inhibition and cortical plasticity in individuals with Neurofibromatosis type 1 using transcranial magnetic stimulation

The primary objectives is to determine the difference in cortical inhibition and cortical plasticity between NF1 patients and unaffected controls.

Pilot Randomized-controlled phase-IIa trial on the prevention of comorbid Depression and Obesity in Attention-deficit / Hyperactivity disorder

Primary objective: To assess the prevention of depressive symptoms by 10-weeks BLT and 10-weeks AEI vs. TAU, and to establish feasibility and effect sizes of these two kinds of interventions in combination with a m-Health app based reinforcement in…