35 results
To identify novel diagnostic and prognostic (bio)markers of Dementia with Lewy Bodies.
to evaluate the feasibility and usability of a brief dementia screening instrument for primary care setting
To determine the prevalence of pruritus and pemphigoid in nursing home patients.To assess the relationship of demographic and medical risk factors with pemphigoid in nursing home patients.To assess the association between pruritus and…
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
Our projects aim to identify (a combination of) putative diagnostics markers for Alzheimer's disease that allow for accurate discrimination and at the same time can be more readily implemented than the currently available markers, i.e. cheaper…
Overall aimThe ultimate goal of our studies is to optimize treatment and reduce treatment related complications in patients with diabetes and cognitive impairmentOur specific objectives are to:1. assess the validity of two self-administered…
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
1. To investigate the differences between healthy older adults with and without cognitive complaints (SCI) and MCI patients in: a) resting state functional connectivity; b) brain structure; and c) cognitive function. 2. To investigate longitudinal…
The research aims to answer the following questions:- Are the concentrations of neopterin, amino acids, HVA, S-100B and BDNF in the blood of patients with Alzheimer's disease differ from those in a matched healthy controls group (matched for…
Databases with multimodal brain imaging data (FDG-PET, VBM, DTI, ASL and resting state fMRI) will be created. From these data image features will be extracted, to be used to create a supervised classification method for associating brain patterns to…
The general aim of this study is to explore how a motivational deficiency (i.e. apathy) related to neurodegenerative diseases is associated with effort and how it can be distinguished from intentional underperformance. We will investigate whether…
The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…
To investigate the effect of late onset depression and inflammation on the pathological progression from MCI to Alzheimer*s disease by determining the correlation of microglia cell activation, β-amyloid deposition, brain volume, peripheral…
The objective of this research project is to extend the knowledge of the prevalence of pain in patients who are admitted to a psychogeriatric wards of two nursing-homes.The key question is: what's the prevalence of pain in a group of nursing-…
To improve the behavioural (neuropsychological) methods for the early diagnosis of Alzheimer*s disease (AD) and other dementias.
The goal of this study is to examine the relation between a standardized observation scale by nurses with the formal results of neuropsychological tests by a neuropsychologist.
Validating a newly developed non-verbal testcase on the distinguishing ability to determine dementia. Validation by comparison through the "seven minute screen".
To determine the characteristics and geriatric comorbidities (such as cognitive disorders, mood disorders, mobility disorders, functional decline, caregiverburden) of heart failure patients aged 70 years and over at heart failure outpatient clinic.
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…