35 results
Databases with multimodal brain imaging data (FDG-PET, VBM, DTI, ASL and resting state fMRI) will be created. From these data image features will be extracted, to be used to create a supervised classification method for associating brain patterns to…
To explore diurnal fluctuation in CSF Aβ40, Aβ42, sAPPβ, t-tau and phospho-tau concentrations over 36 hours as well as cerebral production and clearance rates in healthy elderly volunteers and patients with mild stage of Alzheimer*s disease.…
To investigate the effect of late onset depression and inflammation on the pathological progression from MCI to Alzheimer*s disease by determining the correlation of microglia cell activation, β-amyloid deposition, brain volume, peripheral…
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
Overall aimThe ultimate goal of our studies is to optimize treatment and reduce treatment related complications in patients with diabetes and cognitive impairmentOur specific objectives are to:1. assess the validity of two self-administered…
The objective of this research project is to extend the knowledge of the prevalence of pain in patients who are admitted to a psychogeriatric wards of two nursing-homes.The key question is: what's the prevalence of pain in a group of nursing-…
To improve the behavioural (neuropsychological) methods for the early diagnosis of Alzheimer*s disease (AD) and other dementias.
To determine the characteristics and geriatric comorbidities (such as cognitive disorders, mood disorders, mobility disorders, functional decline, caregiverburden) of heart failure patients aged 70 years and over at heart failure outpatient clinic.
Validating a newly developed non-verbal testcase on the distinguishing ability to determine dementia. Validation by comparison through the "seven minute screen".
The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…
The goal of this study is to examine the relation between a standardized observation scale by nurses with the formal results of neuropsychological tests by a neuropsychologist.
The general aim of this study is to explore how a motivational deficiency (i.e. apathy) related to neurodegenerative diseases is associated with effort and how it can be distinguished from intentional underperformance. We will investigate whether…
What is the comparative efficacy and safety between dementia diagnostics in primary care and dementia diagnostics in a memory clinic for older persons with memory complaints?
The aim of this study is two-fold:1.To elucidate the role of neuroinflammation in FTLD2.To identify biomarkers to predict and monitor disease progression in FTLD3.To differentiate FTLD-TDP from FTLD-tau during life using biomarkers for…
This protocol is a follow-up of a previously submitted protocol (Evaluation of [18F]AV-1451 kinetic modelling in patients with Alzheimer*s Disease and healthy controls, protocol nr. 2014.519), in which the optimal (simplified) kinetic model for [18F…
To examine whether providing feedback to patients immediately after scoring in a non-valid range on a SVT would have an impact on subsequent symptom validity and neuropsychological test performance. Furthermore, we examine treatment-outcome as a…
The main objective of the study is to collect digital data for the tests that are currently hosted on the Cognitive Dx platform and to use this data to develop and refine the existing algorithms that automatically score the test. Secondary…
Determination of possible Alzheimer pathology in the brain and to follow-up participants over time (by means of another research protocol). In addition, its [18F]-label with a half-life of 110 minutes will enable use in hospitals without an on-site…
Primary objective:To explore the natural time course of specific [18F]AV-1451 binding in patients with subjective cognitive decline after two and four year follow upa. To compare rate of change in [18F]AV-1451 binding according to baseline amyloid…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…