177 results
The objective of this project is to assess the applicability of [11C]GMOM for in vivo imaging of the NMDA receptor.
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
The aim of this study is to demonstrate the influence of a serious diagnosis like schizophrenia has happiness in relation to daily activities.
The objective of this pilot study is to collect data in psychotic patients to design a subsequent larger randomised control study. An applied game using biofeedback has been developed by an independent game studio based. This game will be used to…
To establish the validity of the self-report version of the AVHRS-I interview, the AVHRS-Q.
The goal of the proposed work is to understand dysfunction in two components of cognitive control in schizophrenia: response inhibition and monitoring. The aims of this project are to behaviourally characterize response inhibition and monitoring…
The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…
The primary objective of this study is to examine whether web-based Wegweis tool can support processes of shared decision making in ROM evaluation and treatment planning regarding people with psychotic disorders.
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in schizophrenia. Since cognitive dysfunction is the most disabling and untreatable characteristic of…
To examine whether hearing impaired young adults are sensitised to social stress, whether this related to dopaminergic activity and whether theory of mind could mediate the relationship.
Hypotheses of the study:Psycho-education coping skills training is effective in reducing the negative consequences of stigma in people with SMI, in a way thata) quality of life of people with SMI improves;b) social functioning of people with SMI…
Obsessive compulsive symptoms in psychosis: Insight into dynamic interaction and symptom variability
With this research project we aim to investigate the time course and relationship between psychotic, obsessive-compulsive and depressive symptoms and the influence of environmental and individual factors on the course of symptom severity and…
In this project, I wish to take a novel step in understanding the influence of environmental exposures in the aetiology of psychotic disorders, by studying occurrence of (minor) psychotic symptoms and the (correlates of) physiological indicators of…
To study how the registered medicine Midazolam is absorbed, broken-down and excreted by the body after or without administration of multiple doses of the test compound.To study how the registered medicine Dextromethorphan is absorbed, broken-down…
The main goal of our proposal is to study the interaction between cognitive and emotional capacities in schizophrenia. In numerous studies patients with schizophrenia show impairments in all major cognitive domains (6) as well as impairments in the…
The aim of the current study is to investigate which gene-abnormalities can be related to brain deficits and symptoms associated with schizophrenia.
De primary objective is to investigate the relationship between serum levels of before mentioned biochemical parameters (amino acid profile and monoaminergic parameters and the neurotrophic proteins BDNF and S-100B) and the symptomatology at…
Primary objective: To evaluate the influence of fosamprenavir/ritonavir on single-dose pharmacokinetics of olanzapine in healthy volunteersSecondary objective: To evaluate the safety of fosamprenavir/ritonavir combined with single-dose olanzapine in…
Primary ObjectivesThe primary objective is to assess the efficacy (primarily through time to relapse) of long-acting injectable (LAI) paliperidone palmitate compared to treatment as usual with orally administered antipsychotics in monotherapy over…