177 results
The aim of the proposed research is to test the hypothesis that lack of insight in psychosis is associated with reduced activation of brain circuits subserving self-evaluation and emotion regulation and that this relationship is also dependent on…
The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…
HypothesisChildren and adolescents with non-psychotic psychiatric disorders represent a vulnerable group high prone for psychotic symptoms. In contrast with normal populations more pronounced symptom and cognitive profiles will be found predicting…
The aim of this study is to collect data in a structured way in order to explore the tolerability, safety and efficacy of paliperiode ER with treatment schedules which will be used in future clinical practice.
The first objective is measuring striatal D2 receptor binding before and after dopamine depletion with AMPT in the UHR population compared to healthy controls, and investigate whether dopaminergic dysregulation is present prior to transition to…
To investigate whether patients with schizophrenia show reliable and consistent brain activations as measured with fMRI to two different stimulation paradigms and wether they differ in terms of the patterns or the intensity of activation as compared…
In this study we aim to assess dopamine synthesis in healthy subjects with isolated hallucinations using 18F-DOPA PET.
To assess the effects of home automation on client satisfaction with services, functioning, fulfillment of needs for care, quality of life, and service contacts.
The aim of the present study is to investigate the semantic network of patients with psychosis with current auditive hallucinations, patients with psychosis without current auditive hallucinations, first degree relatives of patients with psychosis…
The aim of the project is to apply neuro-economics in order to elucidate mechanisms underlying disturbed social cognition in paranoid delusions at the level of the cognitive mechanisms. This will be done in patients with lifetime presence of non-…
Main objectives: (1) To identify genetic, environmental and clinical determinants of psychosis vulnerability and onset. (2) To assess neural systems and behavioural substrates mediating gene environment interactions. (3) To test for gene-…
Primary Objective: 1. Are the effects of conscious and unconscious priming effects on selfagency different in schizophrenia as compared to health?2. What are the functional and structural neural substrates underlying conscious and unconscious…
Primary objective: the primary goal is to investigate the effect of audiobooks on quality of life, general psychopathology, the experienced power of the voices and the burden of the voices.Secondary objective: the second goal is to determine whether…
Primary study objective Is the reduction of 1 to several antipsychotic antipsychotic associated with more relapse? Relapse is measured with the Brief Psychiatric Rating Scale (BPRS) and is defined as: - An absolute increase of> 2 on one of…
The aim of the study is to explore the effects of two first choice PTSD treatments according to the guidelines, EMDR and prolonged exposure, in patients with a history of psychotic episodes.
The objective of the study is to investigate whether the application of the multidisciplinary guidelines for the treatment of schizophrenia leads to a better course of schizophrenia and related disorders.
The objective of this study is threefold. First, to investigate neural correlates of cognitive-emotional processing in an ARMS sample, i.e. help-seeking young people with an at-risk mental state (this will be addressed in the base-line measurement…
Objectives: To investigate if it is feasible to study giving light therapy to patients with schizophrenia or schizoaffective disorder who are admitted to a clinic. The secondary objectives are to investigate whether light therapy can also help to…
The general purpose of the present study is to test whether people with schizophrenia perform differently when assessing working-memory tasks measuring different components. A better knowledge of working memory impaiment in schizophrenia could lead…
This study examines two two forms of crisis card: (1) crisis card formulated with an independant consulant, (2) crisis card formulated with a clinician.The background of the comparison of the two forms of intervention is that the crisis card…