177 results
This study looks if the third generation antipsychotic aripiprazole can improve activity of the prefrontal cortex and cognitive and social function, when compared to the second generation antipsychotic risperidone.
- to reduce psychological suffering- to improve quality of life- to imprive heartcoherence
To test the following hypotheses:1. The baseline [123I]IBZM binding potential ([123I]IBZM-BP) in the ventral striatum is smaller in patients with SAHI than in healthy subjects, due to increased baseline activity of the mesolimbic dopamine system. 2…
Objective: (1) to develop and apply methods for the detailed assessment of candidate environmental exposures, at both individual and area levels, by using an optimum, family-based, case-control design, in a diverse range of settings across Europe. (…
The aim of this study is to investigate the neural correlates of different types of emotion regulation and emotional processing underlying social cognition.
The aim of this study is to investigate the differences and similarities in AVH in healthy subjects and in patients with different psychiatric disorders. In addition, the underlying biological mechanisms of AVH will be studied in detail:1)…
The aim of this study is to examine three types of motor learning reflecting the function of different brain regions: brain stem, cerebellum and the basal ganglia. Besides the basal ganglia which are one region with a high presence of dopaminergic…
The primary objective of this study is to evaluate the effects of a CYP2D6 inhibitor, paroxetine, on the pharmacokinetics of a single dose of orally administered paliperidone ER. The safety and tolerability of the 3 mg tablet of paliperidone ER…
Studie A:1. To study the psychometric properties of the Dutch version of the PIQ in a non-clinical and clinical sample.2. to study the relationship of persecutory delusions and aggression in a non-clinical and clinical sample.Studie B:3. To test the…
Aim 1: To examine the determinants of aggressive behavior in patients with a psychotic disorder. The main focus is on affective responses to psychotic symptoms which can be predictable for aggressive behavior in these patients. Aim 2: In addition,…
The aim of the present study is to investigate the neural correlates of the semantic network of patients with recent non-affective psychosis, first degree relatives of patients with psychosis and healthy controls. Furthermore, the relationship…
1. Are there differences in the trajectories of brain volume change with age between patients and healthy individuals (longitudinal design)?2. What are the effects of age on white matter integrity in healthy subjects and do patients show…
1)To determine whether subjects at ultra high risk to develop schizophrenia display hepatic insulin resistance as compared to healthy controls matched for age, sex, BMI, ethnicity, visceral and subcutaneous fat mass.2)To determine whether…
Objective: To test the hypothesis that clozapine treatment compared to risperidone treatment is associated with a significant reduction in subjective craving and in a lower activity of the different functional craving pathways and their associated…
1. To compare patient outcomes during follow-up between adherents versus non-adherents with psychoeducation in patients with schizophrenia. We selected *time to (re)hospitalisation* as the most important outcome.2. To assess the prevalence and risk…
The objective of this study is to investigate the relationship between JNJ-37822681 plasma concentration and striatal dopamine D2 receptor occupancy in healthy male subjects.The secondary objective of this study is to investigate the safety and…
This study will assess both implicit and explicit effect expectancies associated with marijuana in individuals with psychotic disorder. We will determine whether such expectancies are different from those of people in the general population. We will…
This study aims to identify the genes that moderate the influence of cannabis use on the symptoms of schizophrenia in order to illuminate the mechanisms of action of cannabis and shed new light on the aetiology of schizophrenia.
Beschrijven van het beloop van de kwaliteit van leven bij patiënten met kanker in samenhang met ziektecognities en copingstijl. Onderzoeken welke determinanten de ervaren kwaliteit van leven (mede) bepalen.
To perform a genetic study of left-handedness and language lateralization as endophenotypes of schizophrenia. The study will make use of 30 extended multigenerational pedigrees with multiple left-handers from Urk, an isolated population in The…