177 results
The main objective of this study is to assess the potential beneficial effects of the prebiotic Galacto-oligosaccharides (GOS) in combination with 2*-fucosyllactose (2*-FL) on the gut microbiota, by showing a relative increase in Bifidobacteria in…
In the ASAP study, we aim to investigate pain associated with capillary sampling in a population of patients with serious psychiatric problems, compared to pain associated with standard venous access. This study is a pilot for a planned larger study…
Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…
This study has been transitioned to CTIS with ID 2024-511560-93-00 check the CTIS register for the current data. The objective of this trial is to collect additional safety data.The further objective of this trial is to collect long-term efficacy…
Primary objectives (after 1 year): - to improve smoking cessation- to reduce number of smoked cigarettes Secondary objectives (after 1 year): - to reduce psychiatric symptoms such as depression, psychotic symptoms and anxiety- to improve physical…
Discovering meaning and patterns in the relationship between experienced discrimination, cultural identity and psychosis in ethnicminorities by centering patients* experiences of in- and exclusion in a particular clinical context.Secondary…
The objective of this study is to pilot this novel VR treatment for social interaction difficulties (VR-SOAP) in preparation of a subsequent randomized controlled trial (RCT). The aim of the study is threefold: 1) to investigate the feasibility and…
1. To assess whether a. Neuromelanin-sensitive MRI (nMRI) is a suitable biomarker for TRb. Plasma DDC activity is a suitable biomarker for TR2. To increase our insight in the role of glutamate in the anterior cingulate cortex (ACC) in TR and assess…
Our study has two primary objectives. The first is to investigate whether EMDR-treatment will lead to a decrease in the negative impact of fear-inducing AVH. The second objective is to investigate whether the EMDR-treatment will also lead to a…
Primary: To assess whether the genetic architecture of this severe SCZ phenotype differs from the broad DSM-based SCZ phenotype.To predict response and side effects after clozapine intakeSecondary:1. To detect genetic associations with the current…
The aim of the current study is to identify how increased genetic risk for developing a psychotic disorder affects brain development by studying neurobiological and neuropsychological, clinical an environmental markers in first and second degree…
To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.
Primary objective of the study is to measure patiënt experience of POC testing. Secondary objectives are correlation of POC testingof antipsychotic blood values with those of the Standard (venous) method and to perform a cost-effectiveness analysis.
This study examines whether MCT is effective in patients with schizophrenia-spectrum disorder and comorbid GAD. It is expected that:a) MCT leads to a significant decrease in worryingb) MCT leads to significant reduction of psychotic symptomsc) The…
The primary aim of this research is to test the psychometric qualities of the Dutch translation of the CAI-NL. The secondary aim of the study is to evaluate the clinical value of the CAI-NL as an instrument in the treatment of people with severe…
This study aims to investigate if and how synaptic density may underlie cognitive deficits and whether functional connectivity is the intermediate step. In patients with psychotic disorders, cognitive function and brain connectivity may be decreased…
Translating neuroimaging findings from research into clinical practice (PSYSCAN):
Clinical High Risk
Primary objective of the current study is to develop and validate a prediction tool focusing on illness onset, course and outcome at an individual level in individuals at high risk for developing psychosis. This will be achieved by combining the…
Primary objective of the current study is to develop and validate a prediction tool focusing on illness course and outcome at an individual level after patients have experienced a first episode of psychosis. This will be achieved by combining the…
During the planned follow-up measurements, (T1 and T2), we anticipate that approximately 20% of the cohort will develop schizophrenia. The partition of the sample into *cases* and *controls* with respect to this diagnosis is the basis of all studies…
The primary goal is to study the feasibility of schematherapy for AVH's.