27 results
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…
To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…
The primary objective of this study is to evaluate in a randomized controlled clinical trial the clinical effectiveness of TAT on the proportion of medication non-adherent patients over 24 months, in schizophrenia outpatients who have poor…
This study aims to investigate the effectiveness of the CARe methodology in terms of rehabilitation, participation, empowerment, hope and confidence, fullfilled needs for care and quality of life. The central research question is: *Does the support…
The objective of this study is to directly test, in humans, the hypothesis that reduced prefrontral control leads to dysregulation of the striatum.
Primary objective of this study is to investigate if the Metacognitive Reflection and Insight Therapy (MERIT) improves metacognitive abilities in people with schizophrenia. Secondary objective is to examine whether improvement in metacognitive…
The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…
Are there indications for differences in feasibility and adverse-effects, between a CBT group and a MBSR group in persons with recent onset schizophrenia or related disorders? Are there indications of effect on severity of distress of both…
To investigate whether the psychomotor and cognitive effects of alcohol are exacerbated by GSK1144814 in healthy subjects.
The aim of this study is to determine whether the treatment is effective in reducing symptoms in patients suffering from AVH*s.
Primary Objective: The aim of this study is to determine a cut-off score at the PQ-16 with the CAARMS for better detection of adolescents 12-18 years at risk. Secondary Objective(s): To study the course of UHR in adolescents 12-18 years over a one…
The aim of the proposed study is to investigate the effects of antipsychotic medication on total brain volume and specific brain structures known to be affected in schizophrenia, such as hippocampus, thalamus, caudate, parietal and prefrontal cortex…
This study has been transitioned to CTIS with ID 2024-518769-80-00 check the CTIS register for the current data. Objective 1: to conduct a pragmatic single blind randomised superiority trial (RCT) testing the following hypotheses:1. social recovery…
To test the effect of a novel VR treatment for social interaction difficulties (VR-SOAP) on quantity and quality of social contacts, leisure activities and social participation of young people with a psychotic disorder. Furthermore, to investigate…
The main objective of this study is to investigate the feasibility of a larger single-blind, randomized trial focused on (cost) effectiveness and safety of ECT vs. aripiprazole addition in patients with schizophrenia spectrum disorders (SSD)…
Our primary objective is to test the effects on researcher-rated severity of PTSD symptoms of a full dose of prolonged exposure therapy (PE), eye movement desensitization and reprocessing therapy (EMDR), cognitive restructuring therapy without…
Primary Objective: To test whether the Feeling Safe-NL programme is more effective in improving wellbeing over time than CBTp (from baseline to 18-month follow-up).Secondary objectives: To test whether the Feeling Safe-NL programme is more effective…
The primary objective of the study is to determine whether DiSCoVR improves social cognition. We are interested in the effect of DiSCoVR on the following social cognitive domains:- Emotion Perception.- Social Perception.- Theory of Mind.The second…