61 results
The proposed experimental pilot study focuses on harm reduction in a specific subpopulation, i.e. in patients with schizophrenia (long-term psychotic disorder) with a suboptimal response to the currently available interventions, smoking a lot of…
The primary aim is to investigate whether six weeks augmentation with clonidine of the antipsychotic treatment will reduce positive and negative symptomatology of treatment resistant schizophrenia patients. Important secondary goals of this project…
In Part 1, a single dose will be administered of RO6889450 or placebo (same formulation but then without the active ingredient RO6889450). The purpose of Part 1 is to investigate how safe RO6889450 is and how well RO6889450 is tolerated. Part 1 will…
Primary:to evaluate the safety and tolerability of EVP-6308 after single and multiple ascending dose administration in healthy subjects.Secondary:to determine the pharmacokinetics of EVP-6308 and select metabolites following single and multiple oral…
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation and cognitive insight in patients with recent onset psychotic symptoms.
Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…
The purpose of the study is optimising current treatments in schizophrenia and explore novel therapeutic options for schizophrenia. The study intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and…
To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
The study will be performed in 2 parts, Parts 1 and 2. The volunteers can only participate in one of the two parts of this study. The purpose of Part 1 of the study is to investigate to what extent RO6806127 is tolerated. It will also be…
Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…
The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…
To examine the effect of L-dopa addition to optimal D2-blocking antipsychotic treatment on positive symptoms, negative symptoms, cognitive symptoms and extrapyramidal symptoms in schizophrenia.
- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.
The main objective is to find a pre- and post-valaciclovir treatment difference in hippocampal inflammation, as measured with positron emission tomography, in schizophrenic patients exposed to a psychotic episode. The secondary objective is to…
The primary objective of this study is to evaluate in a randomized controlled clinical trial the clinical effectiveness of TAT on the proportion of medication non-adherent patients over 24 months, in schizophrenia outpatients who have poor…
to assess the safety and tolerability of single ascending doses of RO5545965 in healthy subjectsto investigate the pharmacokinetics (PK) of RO5545965 (and its metabolite(s) if appropriate)to investigate the pharmacodynamic (PD) effects of…
The primary objectives of the study are to:• Evaluate efficacy of 24 weeks treatment with RO4917838 in the PANSS negative symptom factor score in patients with persistent, predominant negative symptoms of schizophrenia treated with antipsychotics.•…
This study aims to investigate the effectiveness of the CARe methodology in terms of rehabilitation, participation, empowerment, hope and confidence, fullfilled needs for care and quality of life. The central research question is: *Does the support…
The objective of this study is to directly test, in humans, the hypothesis that reduced prefrontral control leads to dysregulation of the striatum.