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Clonidine Augmentation Treatment in Schizophrenia

The primary aim is to investigate whether six weeks augmentation with clonidine of the antipsychotic treatment will reduce positive and negative symptomatology of treatment resistant schizophrenia patients. Important secondary goals of this project…

Effectiveness of Eye Movement Desensitization and Reprocessing on Post Traumatic Stress Disorder in persons with mild intellectual disability and psychosis: A multiple baseline study

The main purpose of this study is to find out whether EMDR is a safe and effective treatment to reduce the symptoms of PTSD in people with mild intellectual disability and borderline intellectual functioning. In addition, it is expected to reduce…

Mentalization-Based Treatment for Psychosis: a randomized controlled trial for outpatients with a nonaffective psychotic disorder.

The primary aim of this study is to examine whether TAU plus MBT-P has a more positive effect on social functioning than TAU only.Secondly it will be examined whether this potential therapeutic effect is driven by an increase in social cognitive…

Dynamic interactive Social Cognition Virtual Reality training (DiSCoVR): a pilot study

Primary ObjectiveIn preparation for a multicentre RCT we want to test the VR SCT for people with psychotic disorders in a feasibility study. We want to evaluate the feasibility and acceptability of VR SCT and improve the intervention protocol using…

Effectiveness of penfluridol (oral long acting neuroleptic) as compared to second generation oral neuroleptics in psychotic disorder patients: an open label randomized controlled trial.

Primary Objective: The aim of this study is to determine the time to all-cause discontinuation of penfluridol (acemap; oral long acting neuroleptic) as compared to second-generation oral neuroleptics (olanzapine, risperidone) using an open label…

An open label study in two parallel groups, each receiving in a randomized, two period, cross-over design two single doses of Risperdal® Consta®, to explore the comparative bioavailability of two different batches of Risperdal® Consta® and the intra subject variability of one Risperdal® Consta® batch after intramuscular administration in healthy volunteers

Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…

European Long-acting Antipsychotics in Schizofrenia Trial EULAST

Primary objective is to compare all cause discontinuation rates in patients with schizophrenia randomized to either one of the two depot medications (aripiprazole depot or paliperidone palmitate) with patients randomized to either one of the two…

A single-center, randomized, investigator/subject-blind, adaptive single-ascending dose (Part 1) and multiple-ascending dose (Part 2), placebo-controlled, parallel study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of RO6889450 following oral administration in healthy subjects.

In Part 1, a single dose will be administered of RO6889450 or placebo (same formulation but then without the active ingredient RO6889450). The purpose of Part 1 is to investigate how safe RO6889450 is and how well RO6889450 is tolerated. Part 1 will…

A DOUBLE-BLIND, ASCENDING SINGLE AND MULTIPLE DOSE, SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC AND FOOD EFFECT STUDY OF EVP 6308 IN HEALTHY VOLUNTEERS.

Primary:to evaluate the safety and tolerability of EVP-6308 after single and multiple ascending dose administration in healthy subjects.Secondary:to determine the pharmacokinetics of EVP-6308 and select metabolites following single and multiple oral…

The effect of Virtual Reality Exposure Therapy (VRET) on social participation in people with a psychotic disorder: a multi-site randomized controlled trial.

The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…

Meta Cognitive Training in patients recovering from recent onset psychosis

To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation and cognitive insight in patients with recent onset psychotic symptoms.

Development of an optimal sampling strategy for clozapine to predict area under the concentration-time curve ratios and the clinical validation of the dried blood spot analysis for clozapine

- To establish a model for TDM and calculate the AUC in patients treated with clozapine.- To clinically validate the DBS analysis method for clozapine. - To determine which sample points or combination of sample point(s) gives the best estimate of…

A RCT on the effectiveness of Behavioral Activation for Negative Symptoms (BANS) for negative symptoms in schizophrenia

Primary objective of the study is to investigate whether Behavioral Activation for Negative Symptoms (BANS) improves negative symptoms. Secondary objective is to investigate whether effects of BANS on negative symptoms is mediated or moderated by…

Optimization of Treatment and Management of Schizophrenia in Europe

The purpose of the study is optimising current treatments in schizophrenia and explore novel therapeutic options for schizophrenia. The study intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and…

Cognitive Behavioural Therapy - Social Functioning In Adolescence with recent onset schizophrenia

To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.

A single-center, randomized, double-blind, adaptive, parallel study to investigate the safety, tolerability, pharmacokinetics (Including the effect of food), and pharmacodynamics of RO6806127 in healthy male subjects.

The study will be performed in 2 parts, Parts 1 and 2. The volunteers can only participate in one of the two parts of this study. The purpose of Part 1 of the study is to investigate to what extent RO6806127 is tolerated. It will also be…

A randomized, double-blind, placebo-controlled study in two parts to investigate in Part 1 the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending dose of RO6799477 in healthy volunteers, and in Part 2 the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple dose of RO6799477 in patients with type 2 diabetes mellitus.

Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…

Validation of the novel PET tracer [18F]PK209 in healthy volunteers: Dosimetry, test-retest, and specific binding to the NMDA receptor

The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.

The influence of Eye Movement treatment on imagery in psychosis

The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…

The effect of Eye Movement Desensitization and Reprocessing on Psychosis: A multiple baseline study.

This study will examine the effectiveness of EMDR in the treatment of psychosis, in patients without PTSD. Primary objective of this study is a first exploration of the efficacy of EMDR in the reduction of psychotic symptoms, perceived power of…