61 results
The aim of this study is the investigate genetic and environmental factors which make a person vulnerable to develop a pychosis and (in patients) affect the progression of a psychosis. A second objective is to investigate the effects of genetic and…
To examine whether symptoms of dissociation in schizophrenia are qualitatively similar or different to symptoms of dissociation in dissociative disorders.
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
Do patients with (recent onset, medicated) psychotic disorder (PDM), in persons at ultra high risk for later psychosis (UHR), in patients with schizophrenia who do not use anti-psychotics anymore (PDUM) report higher levels of trait anxiety (…
The two primary objectives of this study are:(1) to explore whether UHR in adolescence is associated with neurobiological differences at baseline and/or changes in the course of 4-8 year of follow-up as measured using MR-techniques and compared with…
To investigate if persistent pro-inflammatory changes in monocytes and T-cells are associated with exposure to migration early in life, and if these changes mediate the relationship between migration and schizophrenia.
Aim of this proposal is to unravel the changes in functional neural networks in healthy human brain and in schizophrenia at 7T. We hypothesize a difference in brain changes between healthy individuals and patients with schizophrenia and abnormal…
We aim to answer the following research questions: 1. Is there an association between trauma and psychopathology in children? In answering this question we will compare cases to their healthy siblings, cases to controls, and siblings to controls. 2…
The primary objective is to determine the metabolic rate of [18F]-FHBG in the brain of healthy volunteers, for comparison with the metabolic rate that was found in schizophrenic patients in the previous study.
To examine whether mild and subtle induced anxiety or anger increase the extent of the aggressive attitude in stabilized psychotic patients. *Aggression* is operationalised as completing word-stems, a thought experiment, and by a computer game which…
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
The objective of this study is to directly test, in humans, the hypothesis that reduced prefrontral control leads to dysregulation of the striatum.
The goal of the proposed work is to understand dysfunction in two components of cognitive control in schizophrenia: response inhibition and monitoring. The aims of this project are to behaviourally characterize response inhibition and monitoring…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in schizophrenia. Since cognitive dysfunction is the most disabling and untreatable characteristic of…
To examine whether hearing impaired young adults are sensitised to social stress, whether this related to dopaminergic activity and whether theory of mind could mediate the relationship.
Obsessive compulsive symptoms in psychosis: Insight into dynamic interaction and symptom variability
With this research project we aim to investigate the time course and relationship between psychotic, obsessive-compulsive and depressive symptoms and the influence of environmental and individual factors on the course of symptom severity and…
In this project, I wish to take a novel step in understanding the influence of environmental exposures in the aetiology of psychotic disorders, by studying occurrence of (minor) psychotic symptoms and the (correlates of) physiological indicators of…
The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…
De primary objective is to investigate the relationship between serum levels of before mentioned biochemical parameters (amino acid profile and monoaminergic parameters and the neurotrophic proteins BDNF and S-100B) and the symptomatology at…