26 results
The aim of this study is to investigate the neural correlates of different types of emotion regulation and emotional processing underlying social cognition.
Primary objective: the primary goal is to investigate the effect of audiobooks on quality of life, general psychopathology, the experienced power of the voices and the burden of the voices.Secondary objective: the second goal is to determine whether…
The aim of the proposed research is to test the hypothesis that lack of insight in psychosis is associated with reduced activation of brain circuits subserving self-evaluation and emotion regulation and that this relationship is also dependent on…
The objective of this study is threefold. First, to investigate neural correlates of cognitive-emotional processing in an ARMS sample, i.e. help-seeking young people with an at-risk mental state (this will be addressed in the base-line measurement…
- To investigate whether olanzapine influences the (psychomimetic) effects of THC, in particular on the Positive and Negative Syndrome Scale (PANSS) - To further explore the pharmacologic basis of the THC model - To investigate the effects of…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The aim of this study is to demonstrate the influence of a serious diagnosis like schizophrenia has happiness in relation to daily activities.
Beschrijven van het beloop van de kwaliteit van leven bij patiënten met kanker in samenhang met ziektecognities en copingstijl. Onderzoeken welke determinanten de ervaren kwaliteit van leven (mede) bepalen.
To investigate whether patients with schizophrenia show reliable and consistent brain activations as measured with fMRI to two different stimulation paradigms and wether they differ in terms of the patterns or the intensity of activation as compared…
The aim of the current study is to investigate which gene-abnormalities can be related to brain deficits and symptoms associated with schizophrenia.
This study looks if the third generation antipsychotic aripiprazole can improve activity of the prefrontal cortex and cognitive and social function, when compared to the second generation antipsychotic risperidone.
This study will investigate the effectiveness of an interactive smart phone application that provides medication reminders and motivation to take up healthy activities during daily life, with the aim to improve schizophrenic and non-affective…
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…
Discovering meaning and patterns in the relationship between experienced discrimination, cultural identity and psychosis in ethnicminorities by centering patients* experiences of in- and exclusion in a particular clinical context.Secondary…
This study aims to investigate if and how synaptic density may underlie cognitive deficits and whether functional connectivity is the intermediate step. In patients with psychotic disorders, cognitive function and brain connectivity may be decreased…
This research aims to generate knowledge about the sexual experience of clients with an SMI. Possibly the acquired knowledge can be used to create awareness among care providers. The ultimate wish is to adapt the treatment to the sexual experience…
The proposed experimental pilot study focuses on harm reduction in a specific subpopulation, i.e. in patients with schizophrenia (long-term psychotic disorder) with a suboptimal response to the currently available interventions, smoking a lot of…
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…