21 results
The goal of this pilot study is to (i) investigate which measurements are suitable best for the evaluation of (cost) effectiveness, (ii) investigate whether CAT can be given as a nursing intervention (feasability).
The main objective is to find a pre- and post-valaciclovir treatment difference in hippocampal inflammation, as measured with positron emission tomography, in schizophrenic patients exposed to a psychotic episode. The secondary objective is to…
Primary objective: To evaluate the influence of fosamprenavir/ritonavir on single-dose pharmacokinetics of olanzapine in healthy volunteersSecondary objective: To evaluate the safety of fosamprenavir/ritonavir combined with single-dose olanzapine in…
- To investigate whether olanzapine influences the (psychomimetic) effects of THC, in particular on the Positive and Negative Syndrome Scale (PANSS) - To further explore the pharmacologic basis of the THC model - To investigate the effects of…
Primary ObjectivesThe primary objective is to assess the efficacy (primarily through time to relapse) of long-acting injectable (LAI) paliperidone palmitate compared to treatment as usual with orally administered antipsychotics in monotherapy over…
The purpose of the study is to investigate how well LY2165766 is tolerated, and to investigate whether LY2165766 administration is associated with body weight gain in comparison to placebo. Olanzapine is included in this study as a positive control…
The aim of the proposed research is to test the hypothesis that lack of insight in psychosis is associated with reduced activation of brain circuits subserving self-evaluation and emotion regulation and that this relationship is also dependent on…
The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…
In this study we aim to assess dopamine synthesis in healthy subjects with isolated hallucinations using 18F-DOPA PET.
The aim of the present study is to investigate the semantic network of patients with psychosis with current auditive hallucinations, patients with psychosis without current auditive hallucinations, first degree relatives of patients with psychosis…
The aim of the project is to apply neuro-economics in order to elucidate mechanisms underlying disturbed social cognition in paranoid delusions at the level of the cognitive mechanisms. This will be done in patients with lifetime presence of non-…
Primary study objective Is the reduction of 1 to several antipsychotic antipsychotic associated with more relapse? Relapse is measured with the Brief Psychiatric Rating Scale (BPRS) and is defined as: - An absolute increase of> 2 on one of…
The aim of the study is to explore the effects of two first choice PTSD treatments according to the guidelines, EMDR and prolonged exposure, in patients with a history of psychotic episodes.
The objective of the study is to investigate whether the application of the multidisciplinary guidelines for the treatment of schizophrenia leads to a better course of schizophrenia and related disorders.
The objective of this study is threefold. First, to investigate neural correlates of cognitive-emotional processing in an ARMS sample, i.e. help-seeking young people with an at-risk mental state (this will be addressed in the base-line measurement…
Objectives: To investigate if it is feasible to study giving light therapy to patients with schizophrenia or schizoaffective disorder who are admitted to a clinic. The secondary objectives are to investigate whether light therapy can also help to…
Are there indications for differences in feasibility and adverse-effects, between a CBT group and a MBSR group in persons with recent onset schizophrenia or related disorders? Are there indications of effect on severity of distress of both…
To investigate whether the psychomotor and cognitive effects of alcohol are exacerbated by GSK1144814 in healthy subjects.
The aim of the current study is to identify how increased genetic risk for developing a psychotic disorder affects brain development by studying neurobiological and neuropsychological, clinical an environmental markers in first and second degree…